| 植 凡,李先承,梁 辉.肾癌根治术中淋巴结清扫对生存预后的影响[J].安徽医药,2015,19(11):2119-2122. |
| 肾癌根治术中淋巴结清扫对生存预后的影响 |
| The Prognostic Influence of Lymph Node Dissection in Radical Nephrectomy for Renal Cell Carcinoma |
| 投稿时间：2015-04-02 |
| DOI： |
| 中文关键词: 肾细胞癌 肾癌根治术 淋巴结清扫术 生存时间 |
| 英文关键词: renal cell carcinoma radical nephrectomy lymph node dissection survival time |
| 基金项目:辽宁省科技厅科学技术计划项目(No 2011225013) 作者简介:植凡,男,硕士研究生 |
|
| 摘要点击次数: 2889 |
| 全文下载次数: 156 |
| 中文摘要: |
| 目的 比较分析行淋巴结清扫术与未行淋巴结清扫术肾细胞癌患者的生存情况,以期为肾细胞癌的临床治疗提供理论依据。方法 选取2013年1月至2015年1月经该院确诊的肾细胞癌252例,收集患者的年龄、性别、TNM分期、Fuhrman病理分级、是否有淋巴结转移、是否行淋巴结清扫术、是否为非透明细胞癌并随访观察其生存情况。采用Kaplan-meier法和COX回归模型进行生存分析,所有分析均采用SPSS17.0完成。结果 所有患者的生存时间为8~134月,生存分析显示,全部患者的生存时间均值为114.1个月,行清扫术的患者生存时间均值为117.7个月,未行清扫术的生存时间均值为102.9个月,生存分析有统计学意义(χ2=5.091,P<0.05)。对不同TNM分期患者的分析结果显示,T3-4期行淋巴结清扫的患者其生存时间明显高于未进行淋巴结清扫的患者(100.6月 vs 67.7月,P<0.05),但在T1-2期患者中并无统计学差异(110.7月 vs 102.6月,P>0.05)。COX回归分析显示,淋巴结清扫和Fuhrman分级对生存时间有显著性意义(P<0.01)。结论 在施行肾癌根治术时,对TNM分期为T1-2期的患者行淋巴结清扫术与否,对患者的生存时间无影响。而对TNM分期为T3-4期的患者行淋巴结清扫术,可以延长患者的生存时间。 |
| 英文摘要: |
| Objective To compare the survival time between renal cell carcinoma patients with and without lymph node dissection.Methods 252 renal cell carcinoma patients from January 2013 to January 2015 in the First Affiliated Hospital of Dalian Medical University were involved in our study. Kaplan-meier analysis and cox regression were applied for the statistics analysis.All data were treated statistically by SPSS17.0 software. Results The overall survival time of all the patients was 8~134 months, mean survival time was 114.1 month , mean survival time with lymph node dissection was 117.1 month, and 114.1 month without lymph node dissection. The difference had a statistical significance(χ2= 5.091,P<0.05). Mean survival time of T3-4 patients with lymph node dissection was higher than without lymph node dissection (100.6 months vs 67.7 months,P< 0.05), but have no statistical significance in T1-2 patients(110.7 months vs 102.6 months, P>0.05). The cox regression showed Fuhrman's nuclear grade and lymph node dissection had a statistical significance(P< 0.01). Conclusions For T1-2 renal cell carcinoma patients, lymph node dissection has no significance effect. For T3-4 patients, lymph node dissection may be a good choice, but its long-term effect needs more study. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
