| 陈斌.2型糖尿病合并冠心病患者apoB/apoAI比值与冠脉病变的相关性[J].安徽医药,2016,20(1):74-77. |
| 2型糖尿病合并冠心病患者apoB/apoAI比值与冠脉病变的相关性 |
| Relationship between the ratio of apoB/apoAI and coronary artery lesion in type 2 diabetic patients with coronary heart disease |
| 投稿时间：2015-09-12 |
| DOI： |
| 中文关键词: 2型糖尿病 冠心病 载脂蛋白B 载脂蛋白AI |
| 英文关键词: type 2 diabetes mellitus coronary heart disease apolipoprotein B apolipoprotein AI |
| 基金项目: |
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| 中文摘要: |
| 目的 探讨2型糖尿病合并冠心病患者血清载脂蛋白B(apoB)/载脂蛋白AI(apoAI)比值与冠状动脉病变严重程度的相关性。方法 入选2013年9月至2015年8月期间住院接受冠状动脉造影的2型糖尿病患者245例,根据冠状动脉造影结果分为2型糖尿病合并冠心病组158例和2型糖尿病组87例,所有患者均检测空腹血脂和血糖。运用多因素Logistic回归分析apoB/apoAI比值与2型糖尿病患者冠心病发病风险的相关性；并通过偏相关分析研究2型糖尿病合并冠心病患者apoB/apoAI比值与冠状动脉病变支数以及Gensini评分的相关性。结果 多因素Logistic回归分析发现,apoB/apoAI比值为2型糖尿病患者发生冠心病的独立危险因素(OR=6.196,5%CI:1.417~19.081, P<0.001 )；应用偏相关分析发现,校正相关因素后,apoB/apoAI比值与冠状动脉病变支数以及Gensini评分均呈正相关(r=0.236,P<0.001;r=0.257,P<0.001)。结论 ApoB/apoAI比值对2型糖尿病患者的冠心病发病风险以及冠状动脉病变严重程度的评估均有一定的临床意义。 |
| 英文摘要: |
| Objective To explore the relationship between the ratio of apolipoproteinB(apoB)/apolipoproteinAI(apoAI) and the severity of coronary artery lesion in type 2 diabetic patients with coronary heart disease(CHD).Methods In total, 245 type 2 diabetic patients hospitalized from September 2013 to August 2015 were enrolled and classified into a type 2 diabetes mellitus with coronary heart disease group (158 cases) and a type 2 diabetes mellitus group (87 cases) according to the results of coronary angiography. All the patients had fasting lipid profile and fasting blood glucose test. Multivariate Logistic regression was applied to estimate the relationship between the ratio of apoB/apoAI and the risk of CHD in type 2 diabetic patient. Partial correlation analysis was used to analyze the correlation of the ratio of apoB/apoAI with the narrowing vessel number of coronary artery and Gensini scores.Results Multivariate Logistic regression analysis showed that the ratio of apoB/apoAI was an independent risk factor for occurrence of CHD in type 2 diabetic patients(OR=6.196,5%CI:1.417~19.081,P<0.001). Partial correlation analysis showed that the ratio of apoB/apoAI was positively related with the narrowing vessel number of coronary artery(r=0.236, P<0.001) and Gensini scores(r=0.257, P<0.001) after adjusting relevant factors. Conclusion The ratio of apoB/apoAI may have some clinical significance in evaluating the risk of CHD and the severity of coronary artery stenosis in type 2 diabetic patients. |
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