| 郭小芳,文希.多囊卵巢综合征患者血清维生素D水平与肥胖、胰岛素抵抗的相关性分析[J].安徽医药,2016,20(2):283-286. |
| 多囊卵巢综合征患者血清维生素D水平与肥胖、胰岛素抵抗的相关性分析 |
| Correlation analysis of serum vitamin Dwith obesity and insulin resistance in patients with polycystic ovary syndrome |
| 投稿时间：2015-10-09 |
| DOI： |
| 中文关键词: 多囊卵巢综合征 维生素D 肥胖 胰岛素抵抗 |
| 英文关键词: polycystic ovary syndrome vitamin D obesity insulin resistance |
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| 摘要点击次数: 3154 |
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| 中文摘要: |
| 目的 探讨多囊卵巢综合征患者(PCOS)血清维生素D水平与肥胖、胰岛素抵抗的相关性分析。方法 选择2013年12月—2015年3月该院妇产科就诊的118例PCOS为研究对象(PCOS组),选择同期进行健康体检、月经正常的80例育龄期妇女为对照组,比较两组患者的血清25-(OH)D水平、肥胖相关指标(BMI、腰围/臀围比值、瘦素)、胰岛素抵抗相关指标(胰岛素、HOMA-IR、HOMA-β、QUICKI),分析血清25-(OH)D水平与肥胖相关指标和胰岛素抵抗相关指标的相关性。结果 PCOS组血清25-(OH)D的水平和QUICKI指数均明显低于对照组,而PCOS组中BMI指数、腰围/臀围比值、瘦素水平、胰岛素水平、HOMA-IR和HOMA-β均高于对照组,差异均具有统计学意义(P<0.05)。不同体质量指数的PCOS组25-(OH)D水平和QUICKI指数均低于对照组,胰岛素水平、HOMA-IR和HOMA-β均高于对照组,差异均具有统计学意义(P<0.05)。PCOS组中胰岛素抵抗患者25-(OH)D水平低于非胰岛素抵抗患者,BMI指数、腰围/臀围比值、瘦素水平均高于非胰岛素抵抗患者(P <0.05)。相关性的分析结果显示,血清维生素D水平与QUICKI指数呈明显正相关,而与BMI指数、腰围/臀围比值、瘦素水平、胰岛素水平、HOMA-IR和HOMA-β均呈明显的负相关。结论 PCOS血清维生素D水平与肥胖和胰岛素抵抗均呈明显的负相关,三者与PCOS的发生密切相关。 |
| 英文摘要: |
| Objective To investigate the correlation of serum vitamin Dwith obesity and insulin resistance in patients with polycystic ovary syndrome.Methods 118 cases with polycystic ovary syndrome admitted to our hospital during December 2013 to March 2015 were included in this study (i.e.,PCOS group).Meanwhile,80 cases of normal menstruation women in the same period were chosen as control group.The levels of 25-(OH)D in serum,obesity-related indexes (i.e.,BMI,waist/hip ratio,leptin) and insulin resistance related indexes (i.e.,insulin,HOMA-IR,HOMA-β,QUICKI) were compared between these two groups.Also,the correlation of 25-(OH)D with indexes of obesity and insulin resistance were analysed.Results Serum 25-(OH)D level and QUICKI in the PCOS group were significantly lower than the control group,while BMI,waist/hip ratio,leptin,insulin,HOMA-IR and HOMA-β in the PCOS group were higher than the control group,showing statistically significant difference (P<0.05).25-(OH)D levels and QUICKI in different body mass indexes in the PCOS group were lower than the control group.And insulin levels,HOMA-IR and HOMA-β were higher (P<0.05).25-(OH)D levels of patients with insulin resistance in the PCOS group were lower than patients without insulin resistance (P<0.05).And BMI,waist/hip ratio and leptin in the PCOS group were higher than patients without insulin resistance (P<0.05).Correlation analysis showed that serum vitamin Dlevels were positively correlated with QUICKI but significantly negatively correlated with BMI,waist/hip ratio,leptin,insulin,HOMA-IR and HOMA-β.Conclusions Serum vitamin Dlevels showed significantly negative correlation with obesity and insulin resistance in patients with polycystic ovary syndrome.All of the three factors were closely related to the occurrence of polycystic ovary syndrome. |
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