| 许涛,刘和俊.血清白介素-18、基质金属蛋白酶-9及血浆纤维蛋白原与急性冠脉综合征冠脉病变程度的相关性研究[J].安徽医药,2016,20(2):308-311. |
| 血清白介素-18、基质金属蛋白酶-9及血浆纤维蛋白原与急性冠脉综合征冠脉病变程度的相关性研究 |
| Analysis of the relationship between serum IL-18,serum MMP-9,plasma Fib and coronary stenosis severity in acute coronary syndromes |
| 投稿时间：2015-09-16 |
| DOI： |
| 中文关键词: 急性冠脉综合征 冠脉病变程度 血浆纤维蛋白原 白细胞介素-18 基质金属蛋白酶-9 |
| 英文关键词: acute coronary syndrome coronary artery lesion severity fibrinogen interleukin-18 matrix metalloproteinases-9 |
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| 中文摘要: |
| 目的 探讨急性冠脉综合征(ACS)患者血清白介素-18(IL-18)、基质金属蛋白酶-9(MMP-9)、血浆纤维蛋白原(Fib)水平与冠脉病变程度及稳定性的相关性及临床意义。方法 选择该院治疗并行冠状动脉造影(CAG)的急性心肌梗死(AMI)患者41例为AMI组；不稳定型心绞痛(UAP)患者38例为UAP组；稳定型心绞痛(SAP)患者40例为SAP组,同期因胸痛疑似冠心病住院并行CAG检查单支血管狭窄＜50%或者无狭窄的患者40例为对照组。采用酶联免疫吸附法(ELISA)测定患者血清IL-18、MMP-9浓度,采用凝固法检测患者血浆Fib含量,并分析冠心病患者冠脉造影特点。结果 (1)AMI组、UAP组患者血清IL-18、MMP-9、超敏C反应蛋白(hs-CRP)、血浆Fib较对照组、SAP组明显增高(P＜0.05)。相比UAP组,AMI组患者血清IL-18、血浆Fib水平明显增高(P＜0.05);(2)三支病变组血清IL-18、MMP-9、血浆Fib明显高于单支和双支病变组(P＜0.05),且双支病变组血浆Fib高于单支病变组(P＜0.05);(3)极重度病变组血清IL-18、MMP-9、血浆Fib明显高于轻度、中度和重度病变组(P＜0.05)。重度病变组血清IL-18、MMP-9、血浆Fib明显高于轻度病变组,且血浆Fib明显高于中度病变组(P＜0.05);(4)血清IL-18、MMP-9、hs-CRP、血浆Fib与Gensini积分之间具有正相关性(P＜0.01)。结论 血清IL-18、MMP-9、血浆Fib的增加与ACS的发生和冠脉病变严重程度及稳定性密切相关。 |
| 英文摘要: |
| Objective To explore the clinical significance and correlation of serum IL-18,serum MMP-9 ,plasma Fib with the degree and stability of coronary lesions.Methods Patients were assigned into several groups as follows:41 patients with acute myocardial infarction were taken as AMI group,38 with unstable angina pectoris as UAP group ,40 with stable angina pectoris as SAP group,and 40 with negative coronary angiography showing less than 50% stenosis of at least one coronary arterie as control group).The levels of Fib in peripheral blood were detected by solidification method.Immune turbidimetric method and ELISA were used to measure the concentrations of serum IL-18 and MMP-9,respectively.Results (1)The levels of serum IL-18,MMP-9,and plasma Fib in AMI and UAP groups were significantly increased compared with control and SAP groups (P＜0.05).Compared with UAP group,the levels of serum IL-18 and plasma Fib in AMI group were significantly increased (P＜0.05).(2)The levels of serum IL-18,MMP-9,and plasma Fib in triple-vessel disease group were significantly higher than the single-vessel diseasegroup and double-vessel disease group(P＜0.05),the level of plasma Fib in double-vessel disease group was significantly higher than the single-vessel disease group(P＜0.05).(3)The levels of serum IL-18,MMP-9,and plasma Fib in extremely severe lesions group were significantly higher than mild lesions,moderate lesions and severe lesions groups(P＜0.05).The levels of serum IL-18,MMP -9,and plasma Fib in severe lesions group were significantly higher than mild lesions group(P＜0.05),while compared with moderate lesions group,the plasma Fib levels were significantly increased (P＜0.05).(4)Positive correlation was observed between serum IL-18,MMP-9,hs-CRP,plasma Fib and Gensini score in CHD patients (P<0.01).Conclusions The levels of serum IL-18,MMP-9,and plasma Fib are closely related to ACS and severity of coronary lesions. |
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