| 沈惠亮,吴倩,王镜淇,等.天然凝血酶抑制剂的研究进展[J].安徽医药,2016,20(4):617-620. |
| 天然凝血酶抑制剂的研究进展 |
| Research advances of natural thrombin inhibitorsSHEN Hui-liang ,WU Qian ,WANG Jing-qi, et al (Department of Pharmacy,China Pharmaceutical University ,Nanjing, Jiangsu 211198,China)Abstract: |
| 投稿时间：2015-11-13 |
| DOI： |
| 中文关键词: 凝血酶 丝氨酸蛋白酶抑制剂 阴离子外部结合位点 |
| 英文关键词: thrombin serpin anion binding exosite考文献: |
| 基金项目:国家自然科学基金(No 59637050) 作者简介:沈惠亮,男,硕士研究生 |
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| 中文摘要: |
| 凝血酶是丝氨酸蛋白酶的一种,同时具有于抗凝和促凝活性,在血栓形成和止血过程中发挥着重要的作用。而凝血酶之所以能发挥双重作用,与其结构密切相关。因此根据凝血酶的结构特点,设计特异性、高效的凝血酶抑制剂对于更好地了解止血过程和抑制血栓的形成具有重要意义,通过查阅国内外相关文献,现就天然抑制剂对于凝血酶作用机制及其研究意义进行综述。 |
| 英文摘要: |
| Thrombin is one of serine proteases which exerts vital function in both thrombosis and hemostasis owing to its antithrombotic and procoagulant activities.The dual effects of thrombin have close relationship with its structure.It is of great significance to design specific and efficient thrombin inhibitors to better understand the process of hemostasis as well as inhibition of blood clots formation.By reviewing the relevant literatures, the mechanism of natural thrombin inhibitors were thus reviewed. |
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