| 鲁朝玉,许邦龙,王晓晨,等.外周血25-羟维生素D3与冠心病严重程度的研究[J].安徽医药,2016,20(4):723-726. |
| 外周血25-羟维生素D3与冠心病严重程度的研究 |
| Study of the relationship between peripheral blood 25-Hydroxyvitamin D3 with coronary heart disease |
| 投稿时间：2015-12-10 |
| DOI： |
| 中文关键词: 冠心病 维生素D3 白介素6 T细胞亚群 |
| 英文关键词: coronary heart disease vitamin D3 interleukin 6 T cell subgroup |
| 基金项目: |
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| 摘要点击次数: 2731 |
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| 中文摘要: |
| 目的 探讨外周血25-羟维生素D3与冠心病严重程度的关系。方法 选取2015年6—10月该院心内科155例因胸闷胸痛入院并行冠脉造影术(CAG)者,其中冠脉造影正常者51例,冠状动脉粥样硬化组52例,冠心病组(通过CAG术确诊)52例,测定其25-羟维生素D3、CD4+T细胞、CD8+T细胞、CD4+/CD8+比值、白介素6(IL-6)水平,明确相关指标高低与冠心病严重程度的关系。结果 与冠脉正常组及冠状动脉粥样硬化组相比,冠心病患者25-羟维生素D3水平显著降低(P<0.01),而IL-6、CD4+/CD8+比值显著升高(P<0.01)。IL-6、CD4+/CD8+比值、Gensini评分均与25-羟维生素D3呈显著负相关。结论 冠心病患者外周血25-羟维生素D3水平与冠状动脉病变严重程度相关,25-羟维生素D3可能影响冠心病的发生发展。 |
| 英文摘要: |
| Objective To study the relationship between peripheral blood 25-Hydroxyvitamin D3 with coronary heart disease. Methods 155 patients with chest pain admitted to the Cardiology Department of the Second Affiliated Hospital of Anhui Medical University were treated with coronary angiography (CAG). Among all cases, 51 cases had norm coronary artery, 52 cases coronary atherosclerosis, and 52 cases coronary artery disease (CAD). The levels of 25-Hydroxyvitamin D3, CD4+ T lymphocyte, CD8+ T lymphocyte, CD4+/CD8+ ratio, and IL-6 were determined before CAG.Then statistical assessment was carried out to evaluate the association between 25-Hydroxyvitamin D3 and CAD. Results Compared with coronary atherosclerosis group and normal group,peripheral blood 25-Hydroxyvitamin D3 level decreased significantly(P<0.01), while IL-6, CD4+/CD8+ ratio increased significantly(P<0.01) in CAD group. Conclusions Peripheral blood 25-Hydroxyvitamin D3 level is associated with the severity of coronary artery lesions,which may affect the incidence or progress of CAD. |
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