| 卢转娣,王要有,王迪.抗抑郁治疗对高血压合并抑郁患者的血压影响的临床观察[J].安徽医药,2016,20(4):764-767. |
| 抗抑郁治疗对高血压合并抑郁患者的血压影响的临床观察 |
| The clinical observation about antidepressant treatment on the blood pressure of patients with hypertension combined depression clinical observation |
| 投稿时间：2016-01-20 |
| DOI： |
| 中文关键词: 高血压 抑郁症 非洛地平 艾司西酞普兰 |
| 英文关键词: hypertension depression felodipine escitalopram |
| 基金项目:安徽省自然基金青年项目(No 1608085QH210)抗抑郁治疗对高血压合并抑郁患者的血压影响的临床观察卢转娣1,王要有1,王迪2 (1.南京医科大学附属脑科医院心血管内科,江苏 南京 210029;2.安徽省立医院,安徽 合肥 230001) 抗抑郁治疗对高血压合并抑郁患者的血压影响的临床观察卢转娣1,王要有1,王迪2 |
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| 中文摘要: |
| 目的 探讨合并抑郁的高血压患者在抗高血压治疗基础上行抗抑郁治疗对血压控制影响。方法 选择2014年9月—2015年10月期间在该院就诊的合并抑郁的高血压患者80例,随机均分为A组(抗抑郁治疗组)和B组(对照组),每组40例。在口服非洛地平(5 mg·d-1,每天1次)行抗高血压治疗的基础上,A组予口服艾司西酞普兰(10 mg,每天1次)；B组口服安慰剂,每天1次。疗程4周。两组均观察记录每周治疗后患者的重复测量的血压1次,采用汉密尔顿抑郁量表评价抑郁疗效。观察治疗期间患者不良反应的发生情况。 结果 两组治疗后,血压均较基础值明显下降,且维持在正常范围。治疗第4周,A组收缩压和舒张压较B组明显降低,差异有统计学意义(P＜0.05)。治疗4周后,A组汉密尔顿评分较B组明显降低,抑郁症状明显减轻(P＜0.05)。治疗期间,A组体位性低血压与头晕症状较发病率B组明显增加,差异有统计学意义(P＜0.05)。结论 合并抑郁的高血压患者行抗抑郁治疗时,控制抑郁症状效果确切,较单独使用抗高血压药物时血压控制更低,但体位性低血压,头晕等并发症发生率有所增加,临床治疗应根据患者情况做适当调整。 |
| 英文摘要: |
| Objective Explore the merge depression in patients with high blood pressure in the antihypertensive therapy based uplink antidepressant treatment effect on blood pressure control. Methods 80 cases of hypertensive person with depression from clinic were randomly divided into group Aincluding 40 cases (antidepressant treatment group )and group Bincluding 40 cases (control group) during september 2014 to October 2015, of which the people in group Atreated with felodipine and escitalopram together ,minewhile felodipine and placebo once daily in Group Bfor 4 weeks. Blood pressure of both groups were observed and recorded weekly, Using Hamilton depression scale for evaluating the effect of depression. The occurrence of adverse reactions in patients with observed during treatment.Results The outcome were shown the blood pressure in two groups were significantly decreased when compared with baseline, and pressure and Hamilton values in group Awere significantly lower compared with group Bafter 4 weeks(P＜0.05).But some symptoms such as hypotension and dizziness in group Awere significantly increased(P＜0.05).Conclusions Merge depression of patients with high blood pressure antidepressant treatment, the control effect of depressive symptoms, exactly is the use of antihypertensive drugs alone lower blood pressure control, but orthostatic hypotension, dizziness, increased incidence of complications, such as clinical treatment should be adjusted according to patients condition. |
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