| 戴超,李向培.系统性红斑狼疮Th17细胞分子调控机制研究进展[J].安徽医药,2016,20(5):817-820. |
| 系统性红斑狼疮Th17细胞分子调控机制研究进展 |
| Research development of Th17 cells and its molecular regulatory mechanism in SLE |
| 投稿时间：2016-01-13 |
| DOI： |
| 中文关键词: 红斑狼疮,系统性 T淋巴细胞亚群 白细胞介素17 综述 |
| 英文关键词: lupus erythematosus,systemic T-Lymphocyte Subsets Interleukin-17 Review |
| 基金项目:国家自然科学基金(No 81373186) |
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| 中文摘要: |
| 系统性红斑狼疮(SLE)是一种典型的多系统炎症性自身免疫性疾病,发病机制复杂。Th17细胞是一种以分泌IL-17为主的CD4+T细胞亚群,与肿瘤、感染、过敏以及自身免疫性疾病等相关。Th17细胞生物学特性及其相关的细胞因子与其致病机制密切相关,研究发现Th17细胞在SLE的发生发展中发挥重要作用。归纳近年来Th17细胞的研究进展,探讨其在SLE可能的发病机制,为治疗提供新的依据。 |
| 英文摘要: |
| Systemic lupus erythematosus (SLE) is a kind of typical inflammatory autoimmune diseases with multisystem involvement,the pathogenesis of which is complex.Th17 is a subset of CD4+T cells predominantly secreting IL-17 which is associated with tumor,infection,allergy and autoimmune diseases.Recent researches reveal the essential role of Th17 cells in SLE development and incidence,its biological characteristics and related cytokines closely related with the pathogenic mechanism.Summarizing the research progress of Th17 cells in recent years to explore the potential pathogenesis of SLE may provide new basis for treatment. |
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