| 解岩,张婷婷.抗心律失常药物对2-APB诱发大鼠心房异位活动的影响[J].安徽医药,2016,20(5):832-835. |
| 抗心律失常药物对2-APB诱发大鼠心房异位活动的影响 |
| Inhibition of 2-aminoethoxydiphenyl-borate-induced rat atrial ectopic activity by antiarrhythmic drugs |
| 投稿时间：2016-01-11 |
| DOI： |
| 中文关键词: 钠钙交换体抑制剂DHC 抗心律失常药 利多卡因 奎尼丁 维拉帕米 大鼠,Wistar 2-APB |
| 英文关键词: Anti-Arrhythmia Agents Lidocaine Quinidine Verapamil Rats,Wistar 2-Aminoethoxydi pheny borate |
| 基金项目: |
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| 中文摘要: |
| 目的 研究抗心律失常药物对2-APB诱发的大鼠心房异位活动的抑制作用。方法 通过连接多通道分析和获取数据的等长张力传感器测量2-APB诱发的异位活动。结果 2-APB剂量依赖性增加左心房的异位活动,浓度分别为 1、5、10、20、50 μmol·L-1。抗心律失常药物,奎尼丁(10 μmol·L-1),利多卡因(10 μmol·L-1),维拉帕米(5 μmol·L-1)抑制2-APB诱发的异位活动。2-APB诱发的异位活动能被无钙液和Na+/Ca2+交换抑制剂所阻断,如3′,4′-dichlorobenzamil hydrochloride (DHC)和Ni2+,而不能被非选择性阳离子通道阻断剂 Gd3+所阻断。结论 2-APB诱发的心房异位活动能被经典抗心律失常药物所抑制,如奎尼丁,利多卡因,维拉帕米和钠钙交换抑制剂。2-APB可用于筛选那些能够非选择性抑制钠通道,钙通道和钠钙交换体的抗心律失常药物。 |
| 英文摘要: |
| Objective To explore the inhibition of 2-APB-induced rat atrial ectopic activity by antiarrhythmic drugs.Methods 2-APB-induced ectopic activity was measured through an isometric force transducer connected to amultichannel acquisition and analysis system.Results 2-APB dose-dependence increased the ectopic activity of left atria at 1,5,10,0,50 μmol·L-1.Anti-arrhythmic drugs,quinidine(10 μmol·L-1),lidocaine (10 μmol·L-1),verapamil (5 μmol·L-1) inhibited 2-APB-induced ectopic activity.2-APB-induced ectopic activity was inhibited by Ca2+-free bath,Na+/Ca2+ exchanger blockers,3’,4’-dichlorobenzamil hydrochloride (DHC) and Ni2+,not by non-selective cation channel blocker Gd3+. Conclusions 2-APB-induced atrial ectopic activity was inhibited by classic anti-arrhythmic drugs quinidine,lidocaine,verapamil,and Na+/Ca2+ exchanger blockers.It can be used for testing agents able to affect any of Na+,Ca2+ channel,Na+/Ca2+exchanger without selectivity. |
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