| 吴卫东.离子色谱法测定艾附暖宫丸中9种无机阴离子含量[J].安徽医药,2016,20(6):1068-1071. |
| 离子色谱法测定艾附暖宫丸中9种无机阴离子含量 |
| Determination of 9 inorganic anions in Aifunuangong pills using accelerated solvent extraction and ion chromatography |
| 投稿时间：2016-02-14 |
| DOI： |
| 中文关键词: 中药化学成份 色谱法,离子交换 阴离子 艾附暖宫丸/分析 |
| 英文关键词: Chemical principles (tcd) Chromatography,ion exchange Anions Aifunuangong pills/analysis |
| 基金项目: |
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| 摘要点击次数: 2545 |
| 全文下载次数: 123 |
| 中文摘要: |
| 目的建立同时测定艾附暖宫丸中9种无机阴离子(氟离子、甲酸根离子、氯离子、亚硝酸根离子、溴离子、硝酸根离子、硫酸根离子、草酸根离子和磷酸根离子)含量的分析方法。方法 采用加速溶剂萃取法萃取,离子色谱法测定。Ion Pac AS11-HC阴离子交换分析柱为色谱柱(250 mm×4 mm),氢氧化钾溶液为淋洗液,梯度洗脱(6～46 mmol·L-1),流速为1.0 mL·min-1,洗脱24 min,柱温为30 ℃,进样量为25 μL。结果 9种无机阴离子达到基线分离,0.1～20 mg·L-1线性关系良好,相关系数为0.999 0～0.999 9范围内,仪器精密度、重复性和稳定性的RSD<3.0%,平均加样回收率为86.3%~113.2%,RSD为0.68%～2.48 %。结论 该方法简便快速和自动化,可用于艾附暖宫丸中9种无机阴离子含量的测定。 |
| 英文摘要: |
| Objective To establish the method for simultaneous determination of nine inorganic anions (fluoride,formate,chloride,nitrite,bromide,nitrate,sulfate,oxalate and phosphate ) in Aifunuangong pills by ion chromatography.Methods The samples were extracted using accelerated solvent extraction (ASE) and determined by ion chromatography.Nine inorganic anions were determined by anion exchange column Ion Pac AS11-HC (250 mm×4 mm),and eluted for 24 min by gradient hydroxide potassium (6～46 mmol·L-1) at the rate of 1.0 mL·min-1 and the temperature of 30 ℃,and the sampling volume was 25 μL.Results Good resolution can be achieved among the above mentioned nine inorganic anions.The nine inorganic anions showed a good linear relationship in the ranges of 0.1～20 mg·L-1 and their linear correlations over the investigated concentration were in the range of 0.999 0～0.999 9,while RSDs of degree of precision,repeatability and stability were lower than 2.0%.The average recoveries were 86.3%~113.2% with relative standard deviation of 0.68%～2.48%,respectively.Conclusions The ion chromatography method is simple,fast and automated for the assay and quality control of nine inorganic anions in Aifunuangong pills. |
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