| 麦华德,顾申红.丹参酮ⅡA磺酸钠注射液对老年肺源性心脏病患者血浆白细胞介素-6、肿瘤坏死因子α的影响[J].安徽医药,2016,20(8):1573-1575. |
| 丹参酮ⅡA磺酸钠注射液对老年肺源性心脏病患者血浆白细胞介素-6、肿瘤坏死因子α的影响 |
| Effects of Tanshinone ⅡA Sodium Injection on plasma interleukin-6,tumor necrosis factor α in elderly patients with pulmonary heart disease |
| 投稿时间：2016-03-24 |
| DOI： |
| 中文关键词: 肺心病 白细胞介素6 肿瘤坏死因子α 丹参酮 治疗结果 老年人 |
| 英文关键词: Pulmonary heart disease Interleukin-6 Tumor necrosis factor-alpha Tanshinone Treatment outcome Aged |
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| 中文摘要: |
| 目的 探究丹参酮ⅡA磺酸钠注射液对老年肺源性心脏病患者血浆白细胞介素-6(IL-6)、肿瘤坏死因子α(TNF-α)的影响。方法 选取88例老年肺源性心脏病患者为研究对象,按照随机数字表法分为观察组和对照组,再选择同期的健康者40例为正常组。对照组接受常规治疗,观察组在对照组基础上给予丹参酮ⅡA磺酸钠注射液,治疗12周后观察并记录两组临床疗效、心肺功能、IL-6、TNF-α等指标的变化及相关反应情况。 结果 观察组治疗前、对照组及正常组血浆IL-6[(108.23±30.34)、(106.63±30.12)、(74.21±31.02) ng·L-1]；TNF-α浓度[(19.23±10.79)、(18.24±11.56)、(14.82±4.35) ng·L-1]及PAP[(58.23±8.79)、(56.06±8.46)、(15.77±7.00)mmHg]比较差异有统计学意义(F值分别为66.24、15.53、88.74,均P=0.000),且观察组、对照组均高于正常组(P<0.01)；观察组在治疗12周后血浆IL-6[(74.23±27.12) ng·L-1与(103±28.02) ng·L-1]、TNF-α浓度[(14.87±5.29) ng·L-1与(17.22±7.26) ng·L-1]及肺动脉压(PAP)[(45.91±5.67) mmHg与(54.11±9.28) mmHg]较对照组治疗12周后明显下降(P值分别为0.025、0.044、0.032)。结论 丹参酮ⅡA磺酸钠注射液降低老年肺源性心脏病患者血浆IL-6、TNF-α浓度及PAP,能够改善患者心肺功能。 |
| 英文摘要: |
| Objective To explore the effect of Tanshinone ⅡA sodium injection on plasma interleukin-6,tumor necrosis factor α on elderly patients with pulmonary heart disease.Methods Eighty-eight cases of elderly patients with pulmonary heart disease treated at Department of Cardiology of The Affiliated Hospital of Hainan Medical University from January 2013 to January 2015 were chosen as the subjects of the study,and were randomized into observation group and control group.Forty healthy people were picked up from people taking physical examination at the same time as normal group.The control group was given routine treatment,while the observation group was treated with Tanshinone ⅡA sodium injection plus routine treatment.After 12 weeks,clinical efficacy,cardiopulmonary function,plasma interleukin-6 (IL-6),tumor necrosis factor α (TNF-α) and other indicators and related reactions were observed and recorded.Results Plasma IL-6,TNF-α concentration and PAP were [(108.23±30.34),(106.63±30.12),(74.21±31.02) ng·L-1],[(19.23±10.79),(18.24±11.56),(14.82±4.35) ng·L-1][(58.23±8.79),(56.06±8.46),(15.77±7.00) mmHg] respectively in observation group before treatment ,the control group and the normal group.The differences were statistically significant (F values were 66.24,5.53,8.74,P=0.000),and the indicators in observation group and control group were higher than those in normal group (P<0.01).Plasma IL-6,TNF-α concentration and PAP were significantly lower in observation group than in control group after 12 weeks of treatment [( 74.23±27.12) ng·L-1 vs (103±28.02) ng·L-1],[(14.87±5.29) ng·L-1 vs (17.22±7.26) ng·L-1] and [(45.91±5.67) mmHg and (54.11±9.28) mmHg] (P values were 0.025,0.044,0.032,respectively).Conclusions Tanshinone ⅡA sodium injection reduces plasma IL-6,TNF-α concentrations and PAP in elderly patients with pulmonary heart disease and can improve their heart and lung functions. |
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