| 吴燕,田姗,孔健,等.以叶酸修饰的乳酸-羟基乙酸共聚物为载体的紫杉醇靶向纳米粒的构建与评价[J].安徽医药,2016,20(10):1852-1856. |
| 以叶酸修饰的乳酸-羟基乙酸共聚物为载体的紫杉醇靶向纳米粒的构建与评价 |
| Establishment and evaluation of targeted paclitaxel nanoparticles with PLGA-PEG-FOL as the carrier |
| 投稿时间：2016-04-27 |
| DOI： |
| 中文关键词: 紫杉醇 乳酸-羟基乙酸共聚物 纳米粒 乳化-分散法 |
| 英文关键词: Paclitaxel PLGA-PEG-FOL Nanoparticles Emulsification-dispersion method |
| 基金项目:全军医学科技青年培育项目(13QNP079) 作者简介:吴燕,女,副主任药师,硕士生导师,研究方向:缓控释及靶向给药系统研究,E-mail:yanjiushi1010@126.com |
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| 中文摘要: |
| 目的 以叶酸修饰的生物可降解材料乳酸-羟基乙酸共聚物(PLGA-PEG-FOL)为载体,构建紫杉醇靶向纳米粒并进行评价。方法 采用乳化-分散法,以溶液稳定性、粒径和包封率为评价指标,通过考察乳化剂的用量、有机相种类、水相与有机相比例、聚合物分子量、药载比、剪切速度等因素对纳米粒制备的影响,确定最优处方和制备工艺,并对纳米粒的形态、粒径、Zeta电位、包封率及载药量进行评价。结果 合成了载体PLGA-PEG-FOL；制备的紫杉醇靶向纳米粒为均匀球形粒子,粒径为(88.2±6.7)nm,Zeta电位为(56.5±4.2)mV,包封率为(92.9±3.2)%,载药量为(4.8±1.3)%。结论 纳米粒制备方法简便易行,重现性好。制备的纳米粒大小均匀,粒度分布较窄,包封率和载药量较高。 |
| 英文摘要: |
| Objective To prepare and evaluate the targeted paclitaxel nanoparticles with biodegradable materials of lactic acid-glycolic acid copolymer modified by folic acid (PLGA-PEG-FOL) as the carrier.Methods The emulsification-dispersion method was used to prepare nanoparticles.The optimum prescription and preparation technology were determined by investigating the influence of the dosage of emulsifiers,the species of organic phase,the proportion of water phase and organic phase,molecular weight of polymer,the proportion of drug particle size and the entrapment efficiency.The nanoparticles were evaluated in terms of the morphology of nanoparticles,particle size,Zeta potential,entrapment efficiency and drug-loading rate.Results PLGA-PEG-FOL was successfully synthesized.The targeted nanoparticle was uniform spherical particle.The particle size was (88.2±6.7) nm,Zeta potential was (56.5±4.2) mV,the entrapment efficiency was (92.9±3.2)%,and the drug-loading rate was (4.8±1.3)%.Conclusions The preparation method of nanoparticles was simple and reproducible.The particle size of nanoparticles was uniform with a narrow size distribution.The entrapment efficiency and drug loadings were high. |
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