| 吕齐欢,马维青,叶启宝,等.初诊2型糖尿病病人脂蛋白(a)与胰岛素抵抗的相关性分析[J].安徽医药,2017,21(3):504-506. |
| 初诊2型糖尿病病人脂蛋白(a)与胰岛素抵抗的相关性分析 |
| Association of lipoprotein(a) and insulin resistance in newly diagnosed type 2 diabetes patients |
| 投稿时间：2016-06-18 |
| DOI： |
| 中文关键词: 脂蛋白A 糖尿病,2型 胰岛素抗药性 因果律 |
| 英文关键词: Lipoprotein(a) Diabetes mellitus,type 2 Insulin resistance Causality |
| 基金项目: |
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| 摘要点击次数: 1954 |
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| 中文摘要: |
| 目的 探讨初诊2型糖尿病(T2DM)病人血清脂蛋白(a)与胰岛素抵抗的关系。 方法 检测95例初诊T2DM病人(T2DM组)和40例健康体检者(NC组)血清生化指标,计算胰岛素抵抗指数(HOMA-IR)。比较两组间各指标的差异。 结果T2DM组Lp(a)为(1.78±0.35)低于NC组的(1.85±0.57 )(t=2.574,P＝0.020)。相关分析显示:Lp(a)与胰岛素、HOMA-IR、三酰甘油呈负相关(P<0.05))。线性回归分析显示:Lp(a)在NC组和T2DM组都与HOMA-IR相关(β=-0.003,P=0.001；β=-0.001,P=0.001)。 结论 Lp(a)在T2DM人群中水平低于正常人群,在两组中都与胰岛素抵抗呈独立的负相关性。 |
| 英文摘要: |
| Objective To investigate the association of serum lipoprotein(a) and insulin resistance in newly diagnosed type 2 diabetes patients. Methods Ninety-five newly diagnosed type 2 diabetes patients (T2DM group) and 40 healthy people (NC group) were enrolled.The serum biochemical indices were detected.Insulin resistance index (HOMA-IR) was calculated.We compared the data statistically of the two groups. Results The level of serum Lp(a) of T2DM group was lower than NC group [(1.78±0.35) vs (1.85±0.57);t=2.574,P=0.020].Pearson correlation analysis showed that Lp(a) was negatively correlated with INS,HOMA-IR and TG.Linear regression analysis showed that in both T2DM group and NC group serum Lp(a) was correlated with HOMA-IR(β=-0.003,P=0.001；β=-0.001,P=0.001). Conclusion The level of Lp(a) is lower in T2DM group than in NC group and it is independently and negatively associated with insulin resistance. |
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