文章摘要
王喆,宋德明,郑元喜,等.苯磺酸氨氯地平叶酸片治疗H型高血压疗效观察[J].安徽医药,2017,21(7):1290-1294.
苯磺酸氨氯地平叶酸片治疗H型高血压疗效观察
Effect of amlodipine besylate folic acid tablets for treating H-type hypertensive
投稿时间:2016-09-13  
DOI:
中文关键词: 原发性H型高血压  苯磺酸氨氯地平叶酸片  同型半胱氨酸  叶酸
英文关键词: 
基金项目:
作者单位E-mail
王喆 安徽医科大学附属安庆医院心内科,安徽 安庆 246003  
宋德明 安徽医科大学附属安庆医院心内科,安徽 安庆 246003 sdming@163.com 
郑元喜 安徽医科大学附属安庆医院心内科,安徽 安庆 246003  
顾崇怀 安徽医科大学附属安庆医院心内科,安徽 安庆 246003  
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中文摘要:
      目的 观察苯磺酸氨氯地平叶酸片对伴有同型半胱氨酸(Hcy)升高的轻、中度原发性高血压病人降血压同时降低血浆Hcy作用的有效性。 方法 选择符合标准的120例Ⅰ级、Ⅱ级原发性H型高血压病人,按苯磺酸氨氯地平叶酸片不同剂量采用随机数字表法分为3组:A组:5 mg/0.4 mg苯磺酸氨氯地平叶酸片 40例;B组:5 mg/0.8 mg苯磺酸氨氯地平叶酸片40例;C组:5 mg苯磺酸氨氯地平片40例。均每天1次,口服,连续服用8周。在入组前测量所有病人的血压、血浆Hcy、血清叶酸,并在治疗第2、4、6、8周进行随访,记录血压、血浆Hcy、心率,并记录不良事件。 结果 最终一共115例病人进入随机试验,A、B、C组降压同时降Hcy的有效率分别为23.08%、26.32%、5.26%。A、B组有效性均优于C组。 结论 苯磺酸氨氯地平叶酸片对于伴血浆Hcy升高的原发性轻、中度高血压病人有效。
英文摘要:
      Objective To investigate the efficacy of amlodipine besylate folic acid tablets in controlling blood pressure and plasma homocysteine for mild-moderate primary hypertensive patients with elevated plasma homocysteine. Methods Totally 120 patients were diagnosed as H-type hypertension.All these patients were randomly assigned into 3 groups:group A (amlodipine besylate folic acid,5 mg/ 0.4 mg) (n=40),group B (amlodipine besylate folic acid,5 mg/0.8 mg) (n=40) and group C (amlodipine besylate,5 mg) (n=40).The medicine was taken once a day,for a total period of 8 weeks.Before entering the group,the patients had to measure the blood pressure,serum homocysteine,and serum folic acid.Blood pressure,plasma homocysteine level and heart rate were examined every 2 weeks. Results A total of 115 hypertensives were enrolled.The effective rates of group A,group Band group Cwere 23.08%,26.32%,and 5.26%,respectively.Compared with group C,both group Aand group Bhad significantly high effectiveness in lowering both blood pressure and homocysteine level. Conclusions Amlodipine besylate folic acid tablets can be used to reduce both blood pressure and plasma homocysteine level for patients with mild-moderate primary hypertension.
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