文章摘要
刘瑞韬,徐晓玲,陶金辉,等.炎性肌病患者血清中细胞因子水平与间质性肺疾病的相关研究[J].安徽医药,2017,21(9):1608-1612.
炎性肌病患者血清中细胞因子水平与间质性肺疾病的相关研究
Correlation of cytokines levels with interstitial lung disease in patients with inflammatory myopathy
投稿时间:2017-02-16  
DOI:
中文关键词: 多发性肌炎  皮肌炎  间质性肺疾病  白细胞介素-6  白细胞介素-8  肿瘤坏死因子α
英文关键词: 
基金项目:安徽省年度重点科研项目(12070403052)
作者单位
刘瑞韬 安徽医科大学附属省立医院风湿免疫科,安徽 合肥 230001 
徐晓玲 安徽医科大学附属省立医院呼吸科,安徽 合肥 230001 
陶金辉 安徽医科大学附属省立医院风湿免疫科,安徽 合肥 230001 
方璇 安徽医科大学附属省立医院风湿免疫科,安徽 合肥 230001 
王钢 安徽医科大学附属省立医院风湿免疫科,安徽 合肥 230001 
陈竹 安徽医科大学附属省立医院风湿免疫科,安徽 合肥 230001 
厉小梅 安徽医科大学附属省立医院风湿免疫科,安徽 合肥 230001 
汪国生 安徽医科大学附属省立医院风湿免疫科,安徽 合肥 230001 
李向培 安徽医科大学附属省立医院风湿免疫科,安徽 合肥 230001 
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中文摘要:
      目的 检测皮肌炎(DM)、多肌炎(PM)患者血清中白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、肿瘤坏死因子α(TNF-α)水平,分析其与间质性肺疾病(ILD)的相关性,探索炎性肌病(IM)伴发ILD新的治疗靶点。方法 收集DM患者35例,其中DM-ILD组17例,DM-非ILD组18例,DM-ILD患者中急性/亚急性间质性肺炎(A/SIP)患者11例,慢性间质性肺炎(CIP)患者6例;PM组15例,其中PM-ILD组6例,PM-非ILD组9例;健康对照组10例,详细记录临床及实验室资料。采用流式CBA法检测血清中IL-6、IL-8和TNF-α的水平。分析三种血清因子与ILD的相关性。结果 (1)DM组IL-6、IL-8、TNF-α水平显著高于HC组(P<0.05);(2)PM组IL-6、IL-8、TNF-α水平显著高于HC组(P<0.05);(3)DM-ILD组IL-6、IL-8、TNF-α水平显著高于DM-非ILD组(P<0.001,<0.001,0.011);PM-ILD组与PM-非ILD组之间差异无统计学意义(P>0.05);(4)IL-6在DM-ILD组表达显著高于PM-ILD组(P=0.013),IL-8和TNF-α在两组之间差异无统计学意义(P>0.05);(5)在DM-ILD组中,IL-6、IL-8、TNF-α在A/SIP组较CIP组显著升高(P<0.05)。结论 DM-ILD中IL-6 、TNF-α、IL-8水平均显著高于DM-非ILD患者;IL-6在DM-ILD患者中显著高于PM-ILD患者;IL-6可能在DM-ILD的发病过程中起到重要作用。
英文摘要:
      Objective To detect the levels of IL-6,IL-8 and TNF-α in serum of patients with dermatomyositis (PM) and polymyositis (DM),to analyze its correlation with interstitial lung disease,and to explore new therapeutic targets for inflammatory myopathy with interstitial lung disease (IM-ILD).Methods Thirty-five patients with DM,15 patients with PM and 10 healthy controls were enrolled in this study.DM patients included 17 patients with DM-ILD,among which 11 patients were acute/subacute interstitial pneumonia (A/SIP),and 6 patients were chronic interstitial pneumonia (CIP),and 18 patients with DM-nonILD.Detailed clinical and laboratory data were collected.The levels of IL-6,IL-8 and TNF-α in serum were measured by flow CBA .The correlation of three serum factors and interstitial lung disease of inflammatory myopathy was analyzed.Results The levels of IL-6,TNF-α and IL-8 in the DM group were significantly higher than those in HC group (P<0.05).The levels of IL-6,TNF-α and IL-8 in PM group were significantly higher than those in HC group (P<0.05).The levels of IL-6,IL-8 and TNF-α in DM-ILD group were significantly higher than that in DM-nonILD group (P<0.001,<0.001,0.011).There was no significant difference between PM-ILD group and PM-nonILD group (P>0.05).The expression of IL-6 in DM-ILD group was significantly higher than that in PM-ILD group (P=0.013),and there were no significant differences in IL-8 and TNF-α between the two groups(P>0.05).In DM-ILD group,the levels of IL-6,IL-8 and TNF-α in A/SIP group were significantly increased,higher than those in CIP group(P<0.05).Conclusions The levels of IL-6,TNF-α and IL-8 in DM-ILD patients were significantly higher than those in DM-ILD patients and the expression of IL-6 in DM-ILD patients was significantly higher than that in PM-ILD patients,which suggested that IL-6 may play an important role in the pathogenesis of DM-ILD.
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