文章摘要
肖蕾,沈飞燕,洪斌,等.血液微小RNA-499对早期诊断急性心肌梗死价值的Meta分析[J].安徽医药,2018,22(1):50-53.
血液微小RNA-499对早期诊断急性心肌梗死价值的Meta分析
The value of microRNA-499 in blood for early diagnosis of acute myocardial infarction:a Meta-analysis
投稿时间:2016-09-26  
DOI:
中文关键词: 微小RNA-499  急性心肌梗死  Meta分析  早期诊断
英文关键词: 
基金项目:
作者单位
肖蕾 复旦大学附属中山医院青浦分院心内科,上海 201700 
沈飞燕 复旦大学附属中山医院青浦分院心内科,上海 201700 
洪斌 复旦大学附属中山医院青浦分院心内科,上海 201700 
姚康 复旦大学附属中山医院青浦分院心内科,上海 201700 
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中文摘要:
      目的 评估病人血液微小RNA-499诊断早期急性心肌梗死的应用价值。方法 通过数据库PubMed、Embase、Medline、Cochrane Library 检索已经发表的英文文献,经文献质量评价后提取研究所需数据,利用Stata 14.0 软件进行Meta分析。结果初步检索出113篇英文文献,经纳入与排除标准筛选后,最终纳入研究的文献共9篇。参与病例数1 091例,合并研究间的异质性I2=23.3%,敏感性0.83,特异性0.88,诊断优势比36,受试者工作特征曲线下面积0.84。结论 血液中微小RNA-499在急性心肌梗死患者是升高的,可以作为早期诊断的分子生物学标志。
英文摘要:
      Objective To evaluate the value of microRNA-499 in blood of patients for early diagnosis of acute myocardial infarction. Methods We searched the English literatures through the database,PubMed,Embase,Medline,Cochrane Library to retrieve the published literature,and conducted quality assessment before extracting the required data.Statistical software Stata 14.0 was used to conduct the Meta-analysis. Results Primary literature retrieved 113 English documents,screening with the inclusion and exclusion criteria,a total of nine documents finally included in this study.The number of involved cases was 1 091,combined heterogeneity between studies was I2=23.3%,sensitivity was 0.83,specificity was 0.88,diagnostic odds ratio was 36,the area under the receiver operating characteristic curve was 0.84. Conclusions Blood microRNA-499 in patients with acute myocardial infarction is increased,so it can be used as molecular biomarkers for early diagnosis.
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