| 张胜,王艳霞,冯立东.外周型直径<2 cm的T1a期肺腺癌患者发生淋巴结转移相关危险因素分析[J].安徽医药,2018,22(1):74-77. |
| 外周型直径<2 cm的T1a期肺腺癌患者发生淋巴结转移相关危险因素分析 |
| Risk factors of lymph node metastasis in patients of T1a lung adenocarcinoma with the peripheral diameter of less than 2 cm |
| 投稿时间：2016-10-11 |
| DOI： |
| 中文关键词: 肺腺癌 淋巴结转移 危险因素 |
| 英文关键词: lung adenocarcinoma lymph node metastasis risk factors |
| 基金项目:河南省科技发展计划项目(14102310087)外周型直径<2 cm的T1a期肺腺癌患者发生淋巴结转移相关危险因素分析张胜,王艳霞,冯立东 (焦作煤业(集团)有限责任公司中央医院肿瘤科,河南 焦作 454102) 外周型直径<2 cm的T1a期肺腺癌患者发生淋巴结转移相关危险因素分析张胜,王艳霞,冯立东 Risk factors of lymph node metastasis in patients of T1a lung adenocarcinoma with the peripheral diameter of less than 2 cmZHANG Sheng,WANG Yanxia,FENG Lidong |
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| 中文摘要: |
| 目的 分析外周型直径<2 cm的T1a期肺腺癌患者发生淋巴结转移相关危险因素。方法 选取T1a期肺腺癌的患者347例,搜集入选对象的所有临床资料,对于行PET-CT检查的患者,记录最大标准摄取值,记录患者术前CT检查情况并分类,对可能影响淋巴结转移的因素进行单因素分析和Logistic多因素分析。结果 347例患者中位随访时间15.7个月,未出现死亡病例；单因素分析显示,影像学特征为实性结节或混合型、肿瘤直径1.0～2.0 cm、癌胚抗原>5 μg·L-1,以及行PET-CT检查最大标准摄取值(SUVmax)>5是淋巴结发生转移的重要危险因素(P＜0.05),非条件Logistic回归分析显示,影像学特征实性结节和混合型是淋巴结发生转移的独立危险因素(OR=13.642,95%CI:12.943～21.816,P＜0.001)；对患者影像学表现与临床病理特征进行分析,影像学表现为纯毛玻璃影的56例患者中,均未发生淋巴结转移,表现为混合型的142例患者,134例(94.4%)未发生淋巴结转移,而表现为实性结节的149例患者,97例(65.1%)未发生淋巴结转移,差异有统计学意义(P＜0.05)。结论 影像学特征为实性结节或部分实性毛玻璃结节是直径<2 cm的T1a期肺腺癌患者发生淋巴结转移的独立危险因素,而影像学特征为纯毛玻璃影的患者一般不存在淋巴结转移。 |
| 英文摘要: |
| Objective To investigate the related risk factors of lymph node metastasis in patients of T1a lung adenocarcinoma with peripheral diameter<2 cm. Methods Totally 347 cases of patients diagnosed as T1a lung adenocarcinoma who were treated at Central Hospital of Jiaozuo Coal Group from December 2011 to February 2014 were selected.All clinical data of the cases were collected.The standard uptake values were recorded for patients with PET-CT examination.Preoperative CT inspections were recorded and classified.The univariate and multi-factor logistic analysis were used to analyze the factors that might affect lymph node metastasis. Results The median follow-up time of 347 cases was 15.7 months；there was no death.Univariate analysis showed that the imaging features of solid nodules or mixed type,tumor diameter within 1.0-2.0 cm,carcinoembryonic antigen>5 μg·L-1,and SUVmax> 5 for patients with PET-CT examination were important risk factors for the occurrence of lymph node metastasis (P＜0.05).Unconditional logistic regression analysis showed that the imaging features of solid nodules and mixed type were independent risk factors for the occurrence of lymph node metastasis (OR=13.642,95%CI:12.943-21.816,P＜0.001).Imaging manifestation and clinical pathological features in patients were analyzed.Fifty-six cases were categorized as pure ground-grass opacities,among whom no lymph node metastasis was found.Of 142 cases with mixed ground-glass opacities,134 cases (94.4%) had no lymph node metastasis,while of 149 cases with solid nodules,97 cases (65.1%) had lymph node metastasis.The difference was statistically significant (P＜0.05). Conclusions The imaging features of solid nodules or mixed type were independent risk factors for lymph node metastasis in patients of T1a lung adenocarcinoma with peripheral diameter<2 cm.But for patients with the imaging feature of pure ground-grass opacities,generally there was no lymph node metastasis. |
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