文章摘要
王鑫,赵伟.法舒地尔联合依那普利治疗慢性阻塞性肺疾病合并肺动脉高压的临床疗效[J].安徽医药,2018,22(1):139-142.
法舒地尔联合依那普利治疗慢性阻塞性肺疾病合并肺动脉高压的临床疗效
Clinical efficacy of fasudil combined with enalaprilin treating chronic obstructive pulmonary disease with pulmonary hypertension
投稿时间:2016-09-07  
DOI:
中文关键词: 法舒地尔  依那普利  慢性阻塞性肺疾病  肺动脉高压  临床疗效
英文关键词: fasudil  enalapril  COPD  PAH  clinical efficacy
基金项目:
作者单位
王鑫 重庆市开州区人民医院呼吸内科,重庆 405400 
赵伟 重庆市开州区大德镇卫生院,重庆 405428 
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中文摘要:
      目的 探讨法舒地尔联合依那普利治疗慢性阻塞性肺疾病(COPD)合并肺动脉高压(PAH)的临床疗效。方法 选取180例COPD合并PAH患者,随机分为观察组(n=90)和对照组(n=90),所有患者均进行常规治疗和服用依那普利,在此基础上,观察组给予法舒地尔静脉滴注。比较两组患者治疗前和治疗后3个月肺动脉压(MPAP)、Tei指数和血气分析、肺功能和相关生物学指标[血浆内皮素-1(ET-1)、超敏C反应蛋白(hs-CRP)、D-二聚体(D-D)、血清降钙素原(PCT)],并对两组患者治疗后的临床疗效进行评估。结果 治疗后,两组患者的MPAP、Tei指数、血二氧化碳分压[p(CO2)]、ET-1、hs-CRP、D-D和PCT水平均明显降低(P<0.05),血氧分压[p(O2)]、动态肺顺应性(CRS)、第1秒用力呼气容积(FEV1)及用力肺活量(FVC)均明显升高(P<0.05),且观察组患者变化的程度均优于对照组(P<0.05)。观察组患者治疗的有效率为81.11%,明显高于对照组患者治疗的有效率,差异有统计学意义(χ2=7.098,P=0.012)。结论 法舒地尔联合依那普利可明显改善COPD合并PAH患者肺功能、Tei指数和相关生物学指标,明显提高COPD合并PAH的临床有效率。
英文摘要:
      Objective To investigate the clinical efficacy of fasudil combined with enalaprilintreating chronic obstructive pulmonary disease with pulmonary hypertension.Methods One hundred and eighty patients with COPD and PAH treated in Department of Respiratory Medicine,People′s Hospital of Kaizhou District from March 2010 to May 2015 were randomly assigned randomly into observation group (n=90) and control group (n=90).All patients underwent routine treatment and oralenalapril.On this basis,observation group underwent intravenous injection of fasudil.The pulmonary arterial pressure (MPAP),Tei index,blood gas analysis,lung function and related biological indicators[plasma endothelin-1 (ET-1),high-sensitivity C-reactive protein (hs-CRP),D-dimer,andplasma endothelin-1 Calcium (PCT)] in two groups before and after three-month treatment were compared.And the clinical efficacy of two groups of patients wasevaluated after treatment. Results After treatment,MPAP,Tei index,p(CO2),ET-1,hs-CRP,D-dimer and PCT levels in two groups were both significantly lower than those before treatment(P<0.05),while p(O2),CRS,FEV1 and FVC in two groups were both significantly increased (P<0.05).In addition,the degree of change in these indexes in observation group were superior to those in control group (P<0.05).The effective rate of patients in observation group was 81.11%,significantly higher than that in control group with statistically significant difference (χ2=7.098,P=0.012). Conclusions Fasudil combined with enalapril can significantly improve the lung function,Tei index and related biological indicators in patients with COPD and PAH and significantly increase the clinical efficacy of COPD and PAH.
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