| 刘双.半夏泻心汤联合西替利嗪治疗过敏性鼻炎的临床疗效观察[J].安徽医药,2018,22(2):320-323. |
| 半夏泻心汤联合西替利嗪治疗过敏性鼻炎的临床疗效观察 |
| Effect of Banxiaxiexin decoction composite cetirizine united therapy against allergic rhinitisLIU Shuang (Department of Otolaryngology Head and Neck Surgery,Dalian Friendship Hospital,Dalian,Liaoning 116001,China) Abstract:Objective |
| 投稿时间：2017-02-05 |
| DOI： |
| 中文关键词: 半夏泻心汤 西替利嗪 过敏性鼻炎 |
| 英文关键词: banxiaxiexin decoction cetirizine allergic rhinitis |
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| 中文摘要: |
| 目的 探讨半夏泻心汤联合西替利嗪对过敏性鼻炎的疗效及对患者免疫功能的影响。 方法 132例过敏性鼻炎患者随机分为对照组和观察组,观察组服用半夏泻心汤及盐酸西替利嗪片,对照组仅服用西替利嗪片；观察两组患者的疗效、血清IgE水平的变化以及复发率。 结果 两组患者血清中免疫球蛋白IgE及致炎性细胞因子肿瘤坏死因子-α(TNF-α)的含量治疗后较治疗前显著下降(P<0.05),抗炎性细胞因子转化生长因子-β(TGF-β)以及白细胞介素-10(IL-10)的含量治疗后较治疗前显著上升(P<0.05)。观察组患者炎性因子分泌下降以及抗炎因子分泌上升的程度高于对照组(P<0.05)；观察组CD4+T亚群所占比例较对照组下降(P<0.05),CD4+CD25+T细胞亚群所占比例较对照组升高(P<0.05)。与对照组相比,观察组患者的复发率显著降低(P<0.05),观察组患者的总有效率虽略高,但两组有效率差异无统计学意义(P>0.05)。 结论 半夏泻心汤联合西替利嗪不仅可以调节外周血中致炎性以及抑炎性细胞因子之间的比例,还可以辅助患者调节不同T细胞亚群的数量。 |
| 英文摘要: |
| Objective To investigate the effect of Banxiaxiexin decoction composite cetirizine united therapy against allergic rhinitis and its impact on the immune function of patients. Methods 132 cases of patients with allergic rhinitis were randomly divided into control group and observation group.The observation group were treated with Banxiaxiexin decoction combined with cetirizine,while control group treated with cetirizine only.Efficacy score of both groups of patients,together with serum IgE level and rate of recurrence was recorded during the treating process. Results After treatment,the levels of immunoglobulin IgE and TNF-α in serum were significantly decreased while the levels of anti-inflammatory cytokines,such as TGF-β and IL-10,which were significantly increased in both groups (P<0.05).The observation group witnesses an enhanced inflammatory cytokine level reduction and anti-inflammatory increase than the control group.The observation group showed a significant increased percentage of CD4+CD25+T cell as well as decreased CD4+T cell percentage (P<0.05).Comparing with the control group,observation group exhibited a significant decreased recurrent percentage,and slightly increased overall efficiency.However the difference of efficiency was not essential in terms of statistical analysis. Conclusions Banxiaxiexin decoction combining with cetirizine can not only regulate the ratio of proinflammatory and inflammatory cytokines in peripheral blood,but also help to restore the balance of different Tcell subsets in the allergic rhinitis patients. |
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