| 刘静,雷艳君,丁凤娇,等.血清白细胞介素-2和白细胞介素-4在糖尿病肾病早期诊断中的意义[J].安徽医药,2018,22(4):638-641. |
| 血清白细胞介素-2和白细胞介素-4在糖尿病肾病早期诊断中的意义 |
| Study on the diagnosis value of the serum IL-2 and IL-4 in early diabetic nephropathy |
| 投稿时间：2016-07-05 |
| DOI： |
| 中文关键词: 糖尿病肾病 白细胞介素-2 白细胞介素-4 |
| 英文关键词: diabetic nephropathy interleukin-2 interleukin-4 |
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| 中文摘要: |
| 目的 分析血清白细胞介素-2(IL-2)和白细胞介素-4(IL-4)在糖尿病肾病(DN)早期诊断中的价值。方法 选取DN患者60例(DN组)、糖尿病患者60例(DM组)和健康体检者60例(对照组),检测其血清IL-2和IL-4水平。结果 各组在性别、年龄、体质量指数(BMI)、收缩压(SBP)、舒张压(DBP)上比较,均差异无统计学意义(P>0.05)。DN组患者尿肌酐(UCr)、血肌酐(SCr)均高于其他两组,均差异有统计学意义(P<0.05)。DN组患者IL-2水平明显低于DM组和对照组,而IL-4水平却高于DM组和对照组。IL-2和IL-4单独作为标志物诊断急性肾衰竭(AKI)时,ROC曲线下面积(AUC)分别为:0.833和0.952(P<0.01),二者联合诊断时,诊断率为100%。结论 IL-2和IL-4联合检测可以相互弥补,提高DN的诊断准确率,有助于临床工作者早期发现DN,提供有效的干预措施,减少病死率。 |
| 英文摘要: |
| Objective To study the serum IL-2 and IL-4 in the early diagnosis of diabetic nephropathy. Methods The patients were divided into two groups,patients with diabetic nephropathy(DN group) and diabetic patients(DM group) and control group,60 cases respectively.ELISA method was used to detect serum IL-2 and IL-4. Results Comparison of groups in gender,age,BMI,SBP,DBP,there were no significant differences(P>0.05).UCr,SCr in DN group was higher than the other two groups,the differences were statistically significant(P<0.05).The level of IL-2 in patients with DN was significantly lower than that of DM patients and healthy controls,and the level of IL-4 was higher than that of DM patients and healthy people.When serum IL-2 and IL-4 as a diagnostic marker of DN individually,the areas under the ROC curve(AUC) were:0.833 and 0.952(P<0.01).The diagnostic rate was 100% when the combination of the two at the time of diagnosis. Conclusions Combined with Sarum IL-2 and IL-4 for detection can make up for each other,and improve the diagnostic accuracy of DN,which contribute to the clinical workers in early detection of DN and provide effective intervention measures,reduce the mortality rate. |
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