文章摘要
龚伟,余强,程继文,等.普萘洛尔与平阳霉素治疗婴儿血管瘤疗效的比较[J].安徽医药,2018,22(4):743-745.
普萘洛尔与平阳霉素治疗婴儿血管瘤疗效的比较
Compare the efficacy of propranolol and pingyangmycin on infant hemangioma treatment
投稿时间:2016-06-24  
DOI:
中文关键词: 平阳霉素  普萘洛尔  婴儿血管瘤
英文关键词: pingyangmycin  popranolol  infantile hemangioma
基金项目:
作者单位
龚伟 西安交通大学第二附属医院小儿外科,陕西 西安 710004 
余强 西安交通大学第二附属医院小儿外科,陕西 西安 710004 
程继文 西安交通大学第二附属医院小儿外科,陕西 西安 710004 
王怀杰 西安交通大学第二附属医院小儿外科,陕西 西安 710004 
吴宣林 西安交通大学第二附属医院小儿外科,陕西 西安 710004 
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中文摘要:
      目的 比较普萘洛尔与平阳霉素在婴儿血管瘤治疗上的疗效。方法 将143例婴儿血管瘤患者分为平阳霉素组和普萘洛尔组,其中,平阳霉素组患者80例,给予局部定期注射平阳霉素治疗血管瘤,普萘洛尔组患者63例,给予规律口服普萘洛尔治疗血管瘤,观察比较两组患者血管瘤治疗效果。结果 两组患者在性别分布(χ2=1.13,P=0.26)、病灶部位分布(χ2=1.23,P=0.54)以及年龄分布(Z=-0.665,P=0.51)上均差异无统计学意义(P>0.05);平阳霉素组患者有效率88.75%,瘤体缩小超过一半的患者占61.25%,普萘洛尔组患者有效率95.24%,瘤体缩小超过一半的患者占84.13%。两组有效率及瘤体面积缩小超过一半比例的差异有统计学意义(P<0.05)。两组均有不同程度和比例的不良反应发生,程度较轻,经对症处理后均好转。结论 普萘洛尔治疗婴儿血管瘤安全有效,不良反应轻,值得作为婴儿血管瘤临床一线治疗来推广。
英文摘要:
      Objective To compare the efficacy of propranolol and Pingyangmycin on infant hemangioma treatment. Methods 143 cases of infantile hemangioma were selected and randomly divided into two groups:pingyangmycin group(80 patients included),who were given locally regular injections of pingyangmycin as a treatment of infantile hemangioma;propranolol group(63 patients included),who were given oral propranolol,therapeutic effects were compared between the two groups. Results The distributions of gender(χ2=1.13,P=0.26),lesion(χ2=1.23,P=0.54) and age(Z=-0.665,P=0.51) had no significant difference between the two groups(P>0.05);efficiency in pingyangmycin group was 88.75%,and the ratio of reduction that more than half was 61.25%,which in propranolol group were 95.24% and 84.13%,and the differences were statistically significant(P<0.05).Both groups had adverse reactions occur,but all side effects were mild,and they were improved after symptomatic treatment. Conclusions Propranolol is a safe and effective treatment of infant hemangioma,light adverse reactions are controlled,it should be promoted as a first-line treatment of infant hemangioma.
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