| 高其宏.Eph受体酪氨酸激酶A2和金属蛋白酶2 在大肠癌组织的表达及其与大肠癌发生发展的关系[J].安徽医药,2018,22(5):857-859. |
| Eph受体酪氨酸激酶A2和金属蛋白酶2 在大肠癌组织的表达及其与大肠癌发生发展的关系 |
| Expression of erythropoietin producing human hepatocellular receptor A2 and MMP-2 in colorectal carcinoma and its correlation with development of colorectal carcinoma |
| 投稿时间：2017-04-19 |
| DOI： |
| 中文关键词: 大肠癌 Eph受体酪氨酸激酶A2 MMP-2 免疫组织化学法 |
| 英文关键词: colorectal carcinoma erythropoietin producing human hepatocellular receptor A2 MMP-2 immunohistochemical method |
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| 摘要点击次数: 2029 |
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| 中文摘要: |
| 目的 探讨Eph受体酪氨酸激酶A2(EphA2)和金属蛋白酶2(MMP-2)在大肠癌组织中的表达及其与临床病理特征和预后关系。 方法 采用免疫组织化学法检测76例大肠癌患者手术标本中癌组织和癌旁组织的EphA2蛋白和MMP-2蛋白表达情况。 结果 EphA2蛋白在大肠癌组织中的表达概率明显高于癌旁组织(92.10％比26.31％,P<0.05),MMP-2蛋白在大肠癌组织中的表达概率同样明显高于癌旁组织(80.20％比15.90％,P<0.05)；EphA2蛋白表达水平与组织分化程度大肠癌、Dukes分期、淋巴结转移、年龄密切关联；MMP-2蛋白表达水平与大肠癌组织学分化程度、Dukes分期、淋巴结转移、年龄密切关联。 结论 EphA2蛋白和MMP-2蛋白在大肠癌组织中的高表达可能在大肠癌的发生、发展过程中发挥重要作用。 |
| 英文摘要: |
| Objective To analyze the expresson of erythropoietin producing human hepatocellular receptor A2 (EphA2) and MMP-2 in colorectal carcinoma and its relationship with clinicpathological features and the prognosis of colorectal carcinoma. Methods The expression of EphA2 and MMP-2 in 76 cases of human colorectal carcinoma tissues and non-can-cerous adjacent colorectal tissues were tested by immunohistochemical method. Results The expression of EphA2 in colorectal carcinoma tissues was higher than that in non-cancerous adjacent colorectal tissues (92.10% vs 26.31%,P<0.001).The expression of MMP-2 in colorectal carcinoma tissues was higher than that in non-cancerous adjacent colorectal tissues (80.2％ vs 15.90%,P<0.001).The expression of EphA2 was related to Dukes stage and histological grade,lymph node metastasis and age.There was a close correlation between the expression of MMP-2 and histological grade,lymph node metastasis and age. Conclusions The over-expression of EphA2 and MMP-2 may play an important role in the development of colorectal carcinoma. |
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