| 曹少红,李敏.益生菌预处理联合四联疗法对根除幽门螺杆菌的效果观察[J].安徽医药,2018,22(5):983-985. |
| 益生菌预处理联合四联疗法对根除幽门螺杆菌的效果观察 |
| Effect of probiotics pre-treatment combined with quadruple therapy in the eradication of helicobacter pylori |
| 投稿时间：2017-07-25 |
| DOI： |
| 中文关键词: 幽门螺杆菌,益生菌,四联疗法 |
| 英文关键词: helicobacter pylori probiotics quadruple therapy |
| 基金项目: |
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| 中文摘要: |
| 目的 探索益生菌预处理联合四联疗法对根除幽门螺杆菌(HP)的影响及其能否减少抗生素的使用疗程。 方法 选取初次经14C-尿素呼气试验(14C-UBT)诊断为HP阳性且证实胃黏膜萎缩和(或)肠化生患者127例。采用随机数字表法分为A、B、C三组,A组予以标准四联疗法,疗程2周；B组先予以益生菌预处理2周,后予以标准四联疗法治疗2周；C组先予以益生菌预处理2周,后予以标准四联疗法1周。比较三组HP根除率及不良事件发生率。 结果 B组(95.35%)与A组(85.71%)、A组与C组(78.57%)根除率比较,均差异无统计学意义(P＞0.05)；B组根除率(95.35%)明显高于C组(78.57%),差异有统计学意义(P＜0.05)。不良反应事件发生率,B(9.30%)、C(4.71%)组明显低于A组(30.95%),差异有统计学意义(P＜0.05)；但C组与B组,差异无统计学意义(P＞0.05)。 结论 益生菌预处理联合四联疗法虽在数值上能提高根除率,但差异无统计学意义；能显著降低不良事件发生率；不能证明能减少抗生素的使用疗程。 |
| 英文摘要: |
| Objective To explore the effect of probiotics pre-treatment combined with quadruple therapy in the eradication of helicobacter pylori (HP) and whether it can reduce the use of antibiotics. Methods One hundred and twenty-seven cases of HP positive diagnosed by 14C-UBT with gastric mucosal atrophy and(or)intestinal metaplasia were collected and randomly assigned into three groups.Group Areceived standard quadruple therapy for two weeks,group Bwere pre-treated with probiotics for two weeks,then received standard quadruple therapy for two weeks,while group Cwere pre-treated with probiotics for two weeks,then received standard quadruple therapy for one week.The incidence of adverse reactions and eradication rate of helicobacter pylori among the three groups were compared. Results The HP eradication rate was higher in group B (95.35%) than group A (85.71%),and the HP eradication rate was higher in group A (85.71%) than group C (78.57%).The differences were not statistically significant (P>0.05).The Hp eradication rate in group Bwas significantly higher than that in group C (95.35% vs 78.57%,P<0.05).The incidences of adverse reactions in group B (9.30%) and group C (4.71%) were significantly lower than that of group A (30.95%).The incidence of adverse reactions in group Cwas lower than that in group B,yet the difference was not statistically significant (P>0.05). Conclusions The probiotics pre-treatment combined with quadruple therapy can increase the rate of eradication,yet without statistical significance,and the incidence of adverse events can be significantly reduced,which can not prove to reduce the use of antibiotics. |
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