| 侯静,韩明锋,刘海清,等.耐多药肺结核48例分析[J].安徽医药,2018,22(6):1055-1057. |
| 耐多药肺结核48例分析 |
| Analysis of 48 cases of multidrug resistance in patients with pulmonary tuberculosis |
| 投稿时间：2016-12-28 |
| DOI： |
| 中文关键词: 结核,肺 结核,抗多种药物性 微生物敏感性试验 药物疗法管理 |
| 英文关键词: Tuberculosis,pulmonary Tuberculosis,multidrug-resistant Microbial sensitivity tests Medication therapy management |
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| 中文摘要: |
| 目的 探讨阜阳地区肺结核患者耐多药状况。 方法 选取2012年1月至2014年7月在阜阳市第二人民医院接受治疗的345例痰结核分枝杆菌培养阳性的肺结核患者,其结核分枝杆菌进行二线药物的耐药性检测,对耐多药进行统计学分析。 结果 345例肺结核患者中,耐多药48例,耐多药率为13.9%。初治患者耐多药率5.2%,复治患者耐多药率21.1%,差异有统计学意义(χ2=17.998,P＜0.001)。男性患者耐多药率为14.0%,女性患者耐多药率为13.3%,差异无统计学意义(χ2=0.020,P=0.886)。青年组、中年组初治患者耐多药率分别为17.6%、18.2%,差异无统计学意义(Fisher确切检验值为1)。青年组、中年组复治患者耐多药率分别为9.8%,21.1%,中年组高于青年组,差异有统计学意义(χ2=4.467,P=0.029)。48例耐多药结核患者转归达到治愈标准仅8例,治疗成功率为16.7%。 结论 阜阳地区耐多药结核形式严峻,应该提高初治病人的治愈率,复治是耐药的危险因素,需要重视中年组耐多药问题,加强耐多药患者的管理,规范治疗,加强对病人实行全程督导短程化疗,以避免或降低耐药率。 |
| 英文摘要: |
| Objective To investigate the situation of multidrug resistance in patients with pulmonary tuberculosis in Fuyang area. Methods Three hundred and forty-five pulmonary tuberculosis patients positive of mycobacterium tuberculosis culture and admitted to The Second People′s Hospital of Fuyang from January 2012 to July 2014 were selected.Their drug resistance of mycobacterium tuberculosis was detected by second-line drug.Multidrug resistance was analyzed. Results Among 345 cases of pulmonary tuberculosis,48 cases were multidrug resistant,and the multidrug resistant rate was 13.9%.The rate of multidrug resistance in newly diagnosed patients was 5.2%,and the rate of multidrug resistance in retreated patients was 21.1%.The difference was statistically significant (χ2=17.998,P<0.001).The rate of multidrug resistance in male patients was 14%,and the multidrug resistance rate in female patients was 13.3%;the difference was not statistically significant (χ2=0.020,P =0.886).The rates of multidrug resistance in groups of young and middle-aged newly diagnosed patients were 17.6% and 18.2%,respectively,and the difference was not statistically significant (Fisher′s exact test value was 1).The rates of multidrug resistance in groups of young and middle-aged retreated patients were 9.8% and 21.1%,respectively.The middle-aged group was higher than the young group.The difference between the middle-aged group and the young group was statistically significant (χ2=4.467,P=0.029).Among 48 cases of multidrug-resistant tuberculosis there were only 8 cases who reached the cure standard;the treatment success rate was 16.7%. Conclusions Multidrug resistant tuberculosis in Fuyang is severe,and the cure rate of the patients should be improved.The retreatment is the risk factor of drug resistance.It is necessary to pay attention to the problem of multidrug resistance in the middle-aged group,strengthen the management of the patients with multidrug resistance,standardize the treatment,and promote the directly-observed treatment strategy for the patients in order to avoid or reduce the rate of resistance. |
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