| 靳小可,黄东平.多参数流式细胞术在多发性骨髓瘤微小残留病变检测中的应用进展[J].安徽医药,2018,22(7):1223-1226. |
| 多参数流式细胞术在多发性骨髓瘤微小残留病变检测中的应用进展 |
| Progress of minimal residual disease assessed by multiparameter flow cytometry in multiple myeloma |
| 投稿时间：2017-03-27 |
| DOI： |
| 中文关键词: 多发性骨髓瘤 流式细胞术 肿瘤, 残余 |
| 英文关键词: Multiple myeloma Flow cytometry, minimal residual disease Neoplasm, residual |
| 基金项目:安徽高校自然科学研究项目(重大项目)(KJ2016SD58) |
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| 中文摘要: |
| 多发性骨髓瘤(MM)是临床常见的浆细胞恶性增殖性疾病,随着对该病研究的不断完善,新检测、治疗方法以及新药物的出现使该类患者获得了更长的生存期和更高的生存质量,但依然有很多患者无法治愈、存在复发的风险或对化疗产生耐药,这对临床的诊断、治疗以及病情监测提出了更高的要求。微小残留病变(MRD)概念的提出,使患者治疗后肿瘤负荷状态得到了更精确的描述,有利于临床监测和评价患者状态并选择恰当的诊疗时机,避免治疗不足或过度治疗。在MRD多种检测手段中,多参数流式细胞术(MFC)以其高灵敏度、快速高效、相对廉价等优点逐渐被越来越多的实验室所应用和推广。笔者对目前MFC在骨髓瘤的MRD检测中的应用情况作一综述。 |
| 英文摘要: |
| Multiple myeloma(MM) is a hematological malignancy of plasmocyte in clinic practice. Although the treatments and researches have improved and more patients survive for much longer time, most patients remain incurable and eventually relapse or become refractory to previous treatments. The efficacy of diagnosis need to be improved on request of clinical demand. Minimal residual disease(MRD) provides more accurate estimations of the burden of tumor cells. It would help to improve monitoring of treatment efficacy and to select appropriate time to avoid over treatment and under treatment. Multiparameter flow cytometry (MFC) is one of current techniques to monitor MRD which is widely used in lots of laboratories because of its high sensitivity, fast, high efficiency, and cost-effective. In this paper, the current application of flow cytometry in myeloma MRD detection is summarized. |
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