文章摘要
梁丰,王爱玲.急性心肌梗死患者血尿酸水平对冠脉病变程度的影响[J].安徽医药,2018,22(7):1282-1285.
急性心肌梗死患者血尿酸水平对冠脉病变程度的影响
The influence of the level of serum uric acid of acute myocardial infarction patients to the degree of coronary artery
投稿时间:2017-09-13  
DOI:
中文关键词: 冠心病  尿酸  血糖  高血压  胆固醇, HDL  胆固醇, LDL  影响因素分析
英文关键词: Coronary disease  Uric acid  Blood glucose  Hypertension  Cholesterol, HDL  Cholesterol, LDL  Root cause analysis
基金项目:安徽高校自然科学研究项目(KJ2015ZD24)
作者单位
梁丰 安徽医科大学第一附属医院心血管内科,安徽合肥 230032 
王爱玲 安徽医科大学第一附属医院心血管内科,安徽合肥 230032 
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中文摘要:
      目的 探讨急性心肌梗死(Acute myocardial infarction,AMI)患者血尿酸水平与其冠脉病变程度之间的关系。方法 收集2015年6月至2017年2月安徽医科大学第一附属医院245例确诊为AMI并行经皮冠状动脉介入术(Percutaneous coronary intervention,PCI)患者的临床资料。根据血尿酸水平把患者分为血尿酸正常组(188例)和血尿酸增高组(57例),根据患者冠脉病变支数和冠脉狭窄程度(Gensini)积分评价其冠脉病变的范围及程度,比较两组的一般临床资料,分析患者血尿酸水平与其冠脉病变的范围及程度的相关性,并使用多重线性回归分析AMI患者冠脉病变程度的可能影响因素。结果 血尿酸增高组与血尿酸正常组在高血压患病率、胆固醇(TC)、甘油三脂(TG)、低密度脂蛋白胆固醇(LDL-C)之间的比较差异有统计学意义(P<0.05);血尿酸增高组PCI 术后慢血流的发生率(29.8%)大于正常组(10.1%)(P<0.05),冠脉病变三支组血尿酸水平三支组的血尿酸水平(364.18±71.58) μmol·L-1高于双支组(337.62±89.60) μmol·L-1及单支组(311.02±79.65) μmol·L-1,且差异具有统计学意义(P<0.05),高于冠脉病变双支组及单支组,冠脉病变双支组血尿酸水平高于单支组(P<0.05);相关分析结果表明,高血压、糖尿病、TC、LDL-C、血尿酸水平与Gensini积分有关( r 分别为0.401、0.275、0.416、0.396、0.450,P<0.05);多元线性回归分析结果显示,高血压、LDL-C、血尿酸水平为冠脉狭窄程度的独立影响因素( P<0.05)。所建立的多元回归方程为:Y( Gensini积分)=16.9+0.14×高血压+0.12×LDL-C (mmol·L-1)+0.42×血尿酸(μmol·L-1)。结论 AMI患者血尿酸水平与冠脉病变的严重程度存在相关,因此冠心病患者血尿酸水平的监测于冠状动脉病变程度的评估及冠心病的防治均有重要的临床意义。
英文摘要:
      Objective To explore the correlationbetween the level of serum uric acid of acute myocardial infarction patients (AMI) andthe degree of coronary artery. Methods In June 2015 to February 2017, clinical data of 245 patients were collectedwho diagnosed with AMI with parallel the percutaneous coronary intervention (PCI) in cardiology of the First Affiliated Hospital of Anhui Medical University. We divided patients into normal group (188 cases) and increased group of the serum uric acid (57 cases) according to the result of serum uric acid, thencompared general clinical data between the two groups, and analyzed the correlation of serum uric acid level with the rang and degree of coronary artery of acute myocardial infarction patients. We analyzed the influencing factors of the degree of coronary artery lesions in patients with AMI by using multiple linear regression analysis. Results There werestatistically significant differences in hypertension prevalence, TC, TG and LDL-C between the increased serum uric acid and normal group (P<0.05).The incidence of coronary slow flow in high serum uric acid group after PCI was 29.8%, which was higher than that in the normal group (10.1%) (P<0.05).The three groups of serum uric acid level (364.18±71.58) μmol·L-1 was higher than coronary lesions coronary artery lesions with double (337.62±89.60) μmol·L-1 and single group (311.02±79.65) μmol·L-1 (P<0.05), and coronary artery lesions with double branch of serum uric acid level washigher than single group (P<0.05). The results of correlation analysis showed that high blood pressure, diabetes, TC, LDL-C, serum uric acid level was associated with Gensini score (r respectively was 0.401,0.275,0.416,0.396,0.450, P<0.05).The results of multiple linear regression analysis showed that the high blood pressure, LDL-C, serum uric acid level were the independence influencing factors for the degree of coronary artery of AMI patients(P<0.05). The multiple regression equation was:y (Gensini score)=16.9+0.14×hypertension+0.12×LDL-C (mmol·L-1)+0.42×serum uric acid (μmol·L-1). Conclusions There iscorrelation for serum uric acid level with degree of coronary artery of AMI patients. So the monitoring of serum uric acid level in patients with coronary artery disease hasimportant clinical significance in assessing of the degree of coronary artery disease and preventing and treating for coronary heart disease.
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