| 宁来轩.卒中相关性肺炎患者C反应蛋白、降钙素原和炎性细胞因子水平变化及其临床意义[J].安徽医药,2018,22(7):1296-1298. |
| 卒中相关性肺炎患者C反应蛋白、降钙素原和炎性细胞因子水平变化及其临床意义 |
| Study on the changes of CRP, PCT and inflammatory cytokines levels in patients with stroke associated pneumonia and its clinical significance |
| 投稿时间：2016-12-09 |
| DOI： |
| 中文关键词: 卒中 C反应蛋白质 降钙素 干扰素γ 白细胞介素1β 白细胞介素4 白细胞介素6 肿瘤坏死因子α |
| 英文关键词: Stroke C-Reactive protein Calcitonin Interferon-gamma Interleukin-1 beta Interleukin-4 Interleukin-6 Tumor necrosis factor-alpha |
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| 中文摘要: |
| 目的 观察卒中相关性肺炎(SAP)患者C反应蛋白(CRP)、降钙素原(PCT)及炎性细胞因子水平的变化。方法 以2015年1月至2016年12月在中信中心医院内科接受治疗的脑卒中患者为研究对象,根据其是否出现卒中相关性肺炎分为SAP组和非SAP组,并根据SAP组患者的预后分为好转组和进展组。观察SAP组和非SAP组、好转组和进展组患者的CRP、PCT和炎性细胞因子水平,分析CRP、PCT与炎性细胞因子水平的相关性。结果 SAP组患者的CRP(3.05±0.98) μg·mL-1和PCT(4.95±1.03) μg·L-1水平高于非SAP组(t=21.623、24.506,P<0.001)；SAP组患者的γ-干扰素(IFN-γ)水平低于非SAP组(t=-41.043,P<0.001),白介素-1β(IL-1β)、白介素-4(IL-4)、白介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)水平高于非SAP组(t=20.407、10.926、17.689、14.421,P<0.001)；进展组的SAP患者的CRP(4.01±0.32) μg·mL-1和PCT(4.95±1.03) μg·L-1水平高于好转组(t=35.894、10.721,P<0.001)；进展组患者的IFN-γ水平低于好转组(t=-37.099,P<0.001),IL-1β、IL-4、IL-6和TNF-α水平高于好转组(t=8.848、5.602、3.405、3.912,P<0.001)。结论 卒中相关性肺炎患者的CRP和PCT和炎性反应水平较高,且与疾病严重情况密切相关。 |
| 英文摘要: |
| Objective To observe the changes of Creactive protein (CRP), procalcitonin (PCT) and inflammatory cytokines in patients with stroke associated pneumonia (SAP). Methods Stroke patients treated in our hospital from January 2015 to December 2016 were selected as the research object, according to whether there was a stroke associated pneumonia were divided into SAP group and non SAP group and according to the prognosis of SAP group were divided into improved group and in the control group. The levels of CRP, PCT and inflammatory cytokines in the SAP and non SAP group, the improvement and the progressive groups were observed, and the correlation between the levels of CRP, PCT and inflammatory cytokines was analyzed. Results The levels of CRP (3.05±0.98) μg·mL-1 and PCT (4.95±1.03) μg·L-1 in group SAP were higher than those in non SAP group (t=21.623,4.506, P<0.001). The level of interferon-γ(IFN-γ) in SAP group was lower than that of non SAP group (t=-41.043, P<0.001), and the levels of interleukin -1β(IL-1β), interleukin -4 (IL-4), interleukin -6 (IL-6) and tumor necrosis factor-α(TNF-α) were higher than those of non SAP groups (t=20.407,0.926,7.689,4.421, P<0.001). The level of CRP and PCT in the patients with SAP in the progressive group was higher than that in the improvement group (t=35.894,0.721, P<0.001), and the level of IFN-γin the progressive group was lower than that in the improvement group (t=-37.099, P<0.001), and the level of IL-1 beta, IL-4, IL-6 and TNF-α was higher than that of the improvement group (t=8.848,5.602,3.405,3.912, P<0.001). Conclusion The levels of CRP and PCT and inflammatory factors are higher in stroke related pneumonia patients, and are closely related to the severity of the disease. |
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