| 陶飞,方国真,施雪英,等.脑梗死患者血清尿酸及胱抑素C水平与颅内动脉狭窄关系的临床分析[J].安徽医药,2018,22(8):1511-1513. |
| 脑梗死患者血清尿酸及胱抑素C水平与颅内动脉狭窄关系的临床分析 |
| Clinical analysis of the relationship between serum uric acid, cystatin Clevel and intracranial arterial stenosis in patients with cerebral infarction |
| 投稿时间：2017-10-23 |
| DOI： |
| 中文关键词: 尿酸 胱抑素C 颅内动脉狭窄 脑梗死 |
| 英文关键词: Uric acid Cystatin C Intracranial arterial stenosis Cerebral infarction |
| 基金项目: |
|
| 摘要点击次数: 1867 |
| 全文下载次数: 573 |
| 中文摘要: |
| 目的 分析脑梗死患者血清尿酸及胱抑素C(Cystatin C,CysC)水平与颅内动脉狭窄的关系。方法 收集107例住院脑梗死患者的临床资料,均完成头颅CTA及常规生化检查,根据颅内大血管近端狭窄程度分为无狭窄组、轻度狭窄组和中重度狭窄组,分别比较三组间性别、年龄、吸烟、饮酒、高血压、糖尿病、三酰甘油、总胆固醇、低密度脂蛋白、尿酸、CysC水平和高尿酸、高CysC的发生率。 结果 三组分别在年龄、性别、吸烟、饮酒、三酰甘油、低密度脂蛋白、总胆固醇方面比较,均差异无统计学意义(P>0.05),轻度狭窄及中重度狭窄组的血清尿酸、CysC水平和高血压、糖尿病、高尿酸、高CysC发生率均显著高于无狭窄组(P<0.05),且中重度狭窄组血清尿酸、CysC水平显著高于轻度狭窄组(P<0.05),Logistic回归分析显示高尿酸、高CysC均是颅内动脉狭窄的独立危险因素(OR=3.200,P=0.035,95%CI:1.088~9.414；OR=3.446,P=0.030,95%CI:1.250~9.498)。结论 高尿酸、高CysC是脑梗死患者颅内动脉狭窄的独立危险因素,其狭窄程度可能与血清尿酸、CysC水平相关,两者之间可能存在协同作用。 |
| 英文摘要: |
| Objective To study the relationship between serum uric acid, cystatin C (CysC) level and intracranial arterial stenosis in patients with cerebral infarction.Methods A total of 107 cases of cerebral infarction patients were examined with brain CTA and routine biochemical. According to the degree of proximal stenosis of intracranial large vessels, patients were divided into no stenosis group, mild stenosis group and moderate or severe stenosis group. The three groups were compared between gender, age, smoking, drinking, hypertension, diabetes, triglyceride, total cholesterol, low-density lipoprotein cholesterol, uric acid, CysC level, incidence of high CysC and hyperuricemia.Results Three groups in age, sex, smoking, drinking, triglyceride, low-density lipoprotein and total cholesterol were no significant difference (P>0.05). The serum uric acid, CysC level and incidence of hypertension, diabetes, hyperuricemia, high CysC in mild stenosis group and moderate or severe stenosis group were significantly higher than that in non stenosis group (P<0.05), the levels of serum uric acid and CysC in the moderate or severe stenosis group were significantly higher than that in the mild stenosis group ( P<0.05). Logistic regression analysis showed that hyperuricemia and high CysC were the independent risk factors of cerebral artery stenosis (OR=3.200, P=0.035,5%CI:1.088~9.414; OR=3.446, P=0.030,5%CI:1.250~9.498).Conclusion Hyperuricemia and high CysC are independent risk factors of intracranial arterial stenosis in patients with cerebral infarction. The degree of stenosis may be related to the levels of serum uric acid and CysC. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
