| 丁玉洁.KL-6在老年间质性肺炎中的表达及意义[J].安徽医药,2018,22(8):1553-1555. |
| KL-6在老年间质性肺炎中的表达及意义 |
| The significance of KL-6 expression in the elderly with interstitial pneumonia |
| 投稿时间：2016-11-25 |
| DOI： |
| 中文关键词: KL-6 间质性肺炎 肺功能 临床意义 |
| 英文关键词: KL-6 Interstitial pneumonia Pulmonary function Clinical significance |
| 基金项目: |
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| 中文摘要: |
| 目的 探讨KL-6在老年间质性肺炎(ILD)中表达及意义。方法 选择老年患者108例,采用不同疾病分为间质性肺炎患者37例(观察组)、其他非质性肺炎患者36例(对照组)以及正常体检老年人35例(正常组),测定三组患者治疗前后的KL-6血清浓度,以此为指标进行对比分析。结果 正常组KL-6平均浓度为(201.17±20.37) U·mL-1,阳性率为0；对照组KL-6平均浓度为(299.75±37.24) U·mL-1,阳性率为14.33%；观察组KL-6平均浓度为(1801.26±185.36) U·mL-1,阳性率为83.78%,三组阳性率比较,差异有统计学意义(P<0.05)。治疗前,观察组血清KL-6水平高于对照组,差异有统计学意义(P<0.05)；治疗后,两组血清KL-6水平均明显降低,P<0.05,且两组血清KL-6水平差异不明显(P>0.05)。血清KL-6 浓度与VC、FVC、DLCO(r=-0.363,P<0.05；r=-0.401,P<0.05；r=-0.396,P<0.05)呈负相关；血清KL-6 浓度与FEV1(r=0.362,P<0.05)呈正相关。结论 KL-6在老年间质性肺炎中表达较高,与患者的肺功能有较高的相关性,可作为老年间质性肺炎的诊断以及康复评价指标。 |
| 英文摘要: |
| Objective To investigate the significance of KL-6 expression in the elderly with interstitial lung disease (ILD).Methods This research included 108 elderly patients in Nantong Second People’s Hospital. All cases were divided into three groups with 37 cases of interstitial lung disease(study group), 36 patients of other pulmonary disease (control group) and 35 cases of normal healthy elderly patients (normal group). The figure of KL-6 in serum berore and after treatment was the point of comparison.Results In the normal group, the average KL-6 concentration was (201.17±20.37) U·mL-1, the positive rate was 0. In the control group, the average KL-6 concentration was (299.75±37.24) U·mL-1, the positive rate was 14.33%. In the study group, average concentration was (1801.26±185.36) U·mL-1, the positive rate was 83.78%. There was a significant statistical difference between these three groups (P<0.05). Before treatment, the serum level of KL-6 in study group was higher than the control group (P<0.05). After treatment, the serum level of KL-6 in the control group and the study group decreased obviously (P<0.05). And there was no significant difference between these two groups in the serum level of KL-6 (P>0.05). The serum KL-6 concentration was negatively correlated with VC (r=-0.363, P<0.05), FVC(r=-0.401,P<0.05), DLCO(r=-0.396, P<0.05), while positively correlated with FEV1(r=-0.362, P<0.05).Conclusion The high concentration of KL-6 in the elderly ILD patients, which closely connection with the lung function of the patients, can be used as the diagnosis and rehabilitation evaluation index of the elderly patients with interstitial pneumonia. |
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