| 施森宝,杨杰,赵韧,等.经皮冠脉介入治疗应用培哚普利保护肾功能77例临床观察[J].安徽医药,2018,22(8):1569-1572. |
| 经皮冠脉介入治疗应用培哚普利保护肾功能77例临床观察 |
| The clinical observation of perindopril for the protection of renal function by percutaneous coronary intervention in 77 cases |
| 投稿时间：2016-09-12 |
| DOI： |
| 中文关键词: 培哚普利 经皮冠状动脉介入治疗 对比剂肾病 |
| 英文关键词: Pefindopril Percutaneous coronary intervention Contrast-induced nephrology |
| 基金项目:安徽省自然科学基金(1508085QH164) |
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| 中文摘要: |
| 目的 观察培哚普利在经皮冠状动脉介入治疗(PCI)前后对患者肾功能的影响。 方法 将入选的147例行冠状动脉支架植入术的患者按随机数字表法分为培哚普利组(77例)和对照组(70例)。培哚普利组术前服用培哚普利(4 mg·d-1)至少 3 d,术后继续服用培哚普利。对照组治疗期间不使用任何血管紧张素转换酶抑制剂(ACEI)类药物。两组患者术中均使用对比剂碘克沙醇造影。记录患者术前1 d,术后1 d、3 d的肌酐、尿酸、血尿素氮(BUN)和肾小球滤过率,分析比较两组患者手术前后肾功能的变化和对比剂肾病(CIN)发生率的差异。 结果 两组术前1 d肌酐、肾小球滤过率、尿酸和BUN均差异无统计学意义(P>0.05),但培哚普利组BUN术后 3 d 较术前 1 d 上升(P<0.05)。对照组肌酐术后 3 d较术前 1 d升高(P<0.05),对照组尿酸术后 3 d较术前 1 d升高(P<0.05),对照组肾小球滤过率术后3 d较术前 1 d下降(P<0.05)。 对照组各项肾功能主要指标术后1 d较术前1 d均差异无统计学意义(P>0.05)。两组患者CIN的发生率差异无统计学意义(P>0.05)。 结论 培哚普利可预防患者冠脉PCI术后应用对比剂引起的肾功能损伤。 |
| 英文摘要: |
| Objective To observe the effect of perindopril on renal function before and after percutaneous coronary intervention (PCI).Methods A total of 147 patients undergoing coronary artery stent implantation were randomly assigned into perindopril group (n=77) and control group (n=70).In the perindopril group,the patients received perindopril with 4 mg daily for at least 3 days,Perindopril was continued after PCI.The control group did not use any angiotensin converting enzyme inhibitors (ACEI) drugs during treatment.Two groups of patients were treated with the contrast agent iodide.The creatinine,uric acid,blood urea nitrogen (BUN) and glomerular filtration rate were recorded for 1 day before PCI,and 1 day,3 days after PCI.The changes of renal function and the incidence of contrast induced nephropathy (CIN) were compared between the two groups before and after PCI.Results Two group serum creatinine,glomerular filtration rate,uric acid for 1 day before PCI had no significant difference (P>0.05),but in the Perindopril group 3 days after PCI,the BUN increased compared with 1 day before PCI (P<0.05).In the control group,3 days after PCI,the serum creatinine and uric acid were higher than 1 day before PCI (P<0.05),respectively;the glomerular filtration rate was decreased compared with 1 day before PCI (P<0.05);the main renal function indexes were lower than 1 day before PCI,but the difference was not statistically significant (P>0.05).There was no significant difference in the incidence of contrast induced nephropathy between the two groups (P>0.05).Conclusion Perindopril prevents renal function injury caused by contrast agent after PCI in patients. |
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