| 王利敏.阿仑膦酸钠在强直性脊柱炎治疗中对骨及软骨代谢指标的影响[J].安徽医药,2018,22(8):1579-1581. |
| 阿仑膦酸钠在强直性脊柱炎治疗中对骨及软骨代谢指标的影响 |
| Effects of alendronate on bone and cartilage metabolism in patients with ankylosing spondylitis |
| 投稿时间：2017-01-06 |
| DOI： |
| 中文关键词: 阿仑膦酸钠 骨及软骨代谢 强直性脊柱炎 |
| 英文关键词: Alendronate sodium Bone and cartilage metabolism Ankylosing spondylitis |
| 基金项目: |
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| 中文摘要: |
| 目的 探讨阿仑膦酸钠在强直性脊柱炎(AS)治疗中对骨及软骨代谢指标的影响。方法 选取AS患者63例,应用随机数字表法分为观察组32例和对照组31例,两组均进行常规治疗,给予来氟米特联合非甾体类抗炎药物(双氯芬酸钠、美洛昔康等)以及钙剂。观察组在对照组治疗基础上加用阿仑膦酸钠。观察并分析两组患者治疗前后血清软骨寡聚基质蛋白(COMP)、骨特异性碱性磷酸酶(BALP)、抗酒石酸酸性磷酸酶异构体5b(TRACP-5b)、骨桥蛋白(OPN)的含量及炎性指标C-反应蛋白(CRP)、红细胞沉降率(ESR)情况。结果 两组治疗前后各项指标差异无统计学意义(P>0.05)；治疗后观察组COMP(4.29±1.41) μg·L-1、TRACP-5b(38.26±13.47) ng·L-1、OPN(26.90±11.07) μg·L-1水平明显低于治疗前COMP(7.48±3.20) μg·L-1、TRACP-5b(49.10±14.10) ng·L-1、OPN(35.51±13.63) μg·L-1(P<0.05),且治疗后观察组低于对照组COMP(6.91±2.81) μg·L-1、TRACP-5b(44.80±10.50) ng·L-1、OPN(32.90±11.69) μg·L-1(P<0.05)；治疗前两组CRP、ESR差异无统计学意义(P>0.05),治疗后两组CRP、ESR均较治疗前明显降低(P<0.05),观察组CRP(6.10±1.42) mg·L-1、ESR(41.42±15.86) mm·h-1较对照组[(25.24±10.68) mg·L-1(50.23±16.35) mm·h-1]降低更明显(P<0.05)。结论 阿仑膦酸钠在AS治疗中,能够抑制患者骨吸收和软骨破坏,使AS患者的骨及软骨代谢异常得以改善,在病情控制中起到一定作用,且安全性高。 |
| 英文摘要: |
| Objective To investigate the effect of alendronate on bone and cartilage metabolism in patients with ankylosing spondylitis.Methods 63 cases of ankylosing spondylitis (as) were selected in our hospital. According to the order of admission, they were randomly divided into observation group (32 cases) and control group (31 cases). Routine treatment was performed in the two groups. leflunomide combined with non steroidal anti-inflammatory drugs (diclofenac sodium, meloxicam etc) and calcium were given. The observation group was treated with alendronate sodium. Serum cartilage oligomeric matrix protein (COMP) and bone specific alkaline phosphatase (BALP), tartrate resistant acid phosphatase 5b (TRACP-5b), osteopontin (OPN) and inflammatory index CRP (c- reactive protein), ESR (erythrocyte sedimentation rate) were analyzed before and after treatment in two groups.Results There was no significant difference between the two groups before treatment, P>0.05. After treatment, the levels of COMP(4.29±1.41) μg·L-1, TRACP-5b(38.26±13.47) ng·L-1 and OPN(26.90±11.07) μg·L-1 were significantly lower in the observation group, P<0.05. There was no significant difference in the indexes of the control group after treatment, P>0.05. Two groups after treatment, the observation group COMP, TRACP-5b, OPN levels were significantly lower than the control group, P<0.05. Two groups before treatment CRP, ESR difference was not statistically significant, P>0.05. After treatment, two groups of CRP, ESR were significantly reduced, P<0.05. Two groups after treatment, the observation group CRP, ESR decreased significantly, P<0.05.Conclusion Alendronate in the treatment of ankylosing spondylitis, play a role in disease control, can inhibit bone resorption and cartilage destruction, improve the metabolism of bone and cartilage in patients with AS, with high security. |
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