文章摘要
范素香.新辅助化疗对早期局部肿块型宫颈癌手术疗效的影响[J].安徽医药,2018,22(8):1585-1587.
新辅助化疗对早期局部肿块型宫颈癌手术疗效的影响
Effect of neoadjuvant chemotherapy on early local tumor type of cervical cancer with surgical treatment
投稿时间:2016-08-19  
DOI:
中文关键词: 新辅助化疗  早期  局部肿块型  宫颈癌  疗效
英文关键词: Neoadjuvant chemotherapy  Early stage  Local mass type  Cervical cancer  Curative effect
基金项目:
作者单位
范素香 潍坊市人民医院院前急救120, 山东 潍坊 261041 
摘要点击次数: 2017
全文下载次数: 586
中文摘要:
      目的 观察新辅助化疗对早期局部肿块型宫颈癌的手术治疗效果的影响。 方法 选择2013年4月至2016年3月住院治疗的局部肿瘤直径在3~4 cm的Ⅱa期宫颈鳞癌患者68例。将患者分为对照组以及观察组,对照组仅行单纯宫颈癌根治术治疗,而观察组在宫颈癌根治术施行之前行新辅助化疗PVB方案(长春新碱+博来霉素+顺铂)。比较两组患者实施宫颈癌手术所需时间、术中出血量、术前肿瘤直径、术中切缘阳性及深肌层浸润等情况,对术前实体肿瘤的疗效评价。 结果 两组患者手术时间、术中出血量及淋巴结转移情况均差异无统计学意义(P>0.05)。观察组肿瘤直径,切缘阳性例数,深肌层浸润例数分别为(2.05±0.32) cm、0例、7例,显著少于对照组的(3.65±0.65) cm、7例、17例,均差异有统计学意义(t=12.64,χ2 =4.99、4.76,均P<0.05)。观察组经过PVB方案新辅助化疗后,6例完全缓解,16例部分缓解,6例无缓解,4例进展,显著高于对照组的单纯手术治疗的疗效,差异有统计学意义(Uc=4.588,P=0.00)。 结论 PVB方案新辅助化疗能显著缩小局部肿瘤直径在3~4 cm的Ⅱa期宫颈鳞癌的肿瘤直径,减少切缘阳性以及深肌层浸润情况,化疗疗效显著。
英文摘要:
      Objective To explore the effect of neoadjuvant chemotherapy on early local tumor type of cervical cancer with surgical treatment. Methods Sixty-eight cases with stage IIa cervical cancer with a diameter of 3 to 4cm,who were hospitalized from April 2013 to March 2016 in Weifang People's Hospital,were selected and assigned into control group and observation group .The control group underwent cervical cancer radical surgery,while the observation group was added with PVB (Vincristine + Bleomycin+Cisplatin) neoadjuvant chemotherapy.The operative time,the amount of blood loss in surgery,preoperative tumor size,the positive incisional margin,and deep muscle infiltration were compared between the two groups,and the efficacy of preoperative solid tumor was evaluated. Results The operation time,blood loss,and lymph node metastasis were not significantly different between two groups (P>0.05).The tumor diameter (2.05±0.32) cm,the number of cases with positive surgical margin (0 case) and the number of cases with deep muscle infiltration (7 cases) in the observation group were significantly less than (3.65±0.65) cm,7 cases,17 cases in the control group;the difference was statistically significant (t=12.64,χ2=4.99,4.76,P<0.05).After PVB neoadjuvant chemotherapy,there were complete remission in six cases,partial remission in 16 cases,no remission in 6 cases,and progress in 4 cases,which were significantly better than the effect of surgery alone in the control group (Uc=4.588,P=0.00). Conclusions Neoadjuvant chemotherapy can significantly reduce tumor diameter of stage IIa cervical cancer with a diameter of 3 to 4 cm,reduce the number of cases with positive surgical margins and cases with deep muscle infiltration and has remarkable effect for cervical cancer.
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