| 杨会杰,任少达,郭瑞娜,等.肿瘤浸润性树突状细胞和血管内皮生长因子在非小细胞肺癌组织中的表达及意义[J].安徽医药,2018,22(9):1696-1700. |
| 肿瘤浸润性树突状细胞和血管内皮生长因子在非小细胞肺癌组织中的表达及意义 |
| Expression and significance of tumor infiltrating dendritic cells and vascular endothelial growth factor in non-small cell lung cancer |
| 投稿时间：2017-03-27 |
| DOI： |
| 中文关键词: 肿瘤浸润性树突状细胞 血管内皮生长因子 非小细胞肺癌 免疫耐受 |
| 英文关键词: Tumor infiltrating dendritic cells Vascular endothelial growth factor Non-small cell lung cancer Immune tolerance |
| 基金项目:国家自然科学基金青年项目(81600087)肿瘤浸润性树突状细胞和血管内皮生长因子在非小细胞肺癌组织中的表达及意义杨会杰1,任少达2,郭瑞娜1, 魏民1,李修顺1,李鸿超1,李莹1 (1.濮阳市油田总医院病理科,河南 濮阳 457001；2.聊城市人民医院呼吸科,山东 聊城 252002) |
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| 中文摘要: |
| 目的 探讨肿瘤浸润性树突状细胞(TIDC)和血管内皮生长因子(VEGF)在非小细胞肺癌组织中的表达水平及临床意义。方法 自2014年1月至2016年12月,连续性收集濮阳市油田总医院收治的非小细胞肺癌患者106例,术中取肿瘤标本,检测肿瘤组织中TIDC和VEGF水平,并分析其与患者其他临床特征的相关性。结果 与健康组织比较,肿瘤组织中TIDC数密度显著降低[(10.58±3.18) 比(18.93±3.26), t=18.877,P=0.000]；VEGF阳性率显著增高(43.45%比11.32%,χ2=26.131,P=0.000)；MHC-Ⅱ阳性DC显著降低[(6.48±1.04)%比(12.57±2.57)%, t=22.615,P=0.000]；CD54阳性DC显著降低[(7.12±1.59)%比(12.81±2.81)%,t=18.144,P=0.000]。与TNM分期为Ⅰ或Ⅱ期的患者相比,Ⅲ或Ⅳ期患者TIDC数密度显著降低[(9.51±2.88)比(11.82±3.58), t=3.680,P=0.000]；VEGF阳性率显著增加(61.40%比20.41%,χ2=18.126,P=0.000)；MHC-Ⅱ阳性DC显著降低[(7.83±1.05)%比(5.32±0.91)%,t=13.186,P=0.000]；CD54阳性DC显著降低[(6.26±1.01)%比(8.12±1.72)%, t=6.900,P=0.000]。与肿瘤细胞为高分化的患者相比,中低分化的患者TIDC数密度显著降低[(9.58±2.58)比(12.37±3.13), t=4.941,P=0.000]；MHC-Ⅱ阳性DC显著降低[(6.01±1.09)%比(7.32±0.93)%, t=6.244,P=0.000]；CD54阳性DC显著降低[(6.66±1.68)%比(7.94±1.58)%,t=3.842,P=0.000]。结论 TIDC在肿瘤组织中低表达,且多为不成熟的调节性DC细胞,VEGF在肿瘤组织中高表达,均与患者临床预后恶化有关。 |
| 英文摘要: |
| Objective To investigate the expression and significance of tumor infiltrating dendritic cells (TIDC) and vascular endothelial growth factor (VEGF) in non-small cell lung cancer.Methods From January 2014 to December 2016,6 patients with non-small cell lung cancer in Puyang Oilfield General Hospital were consecutively collected.,TIDC,VEGF of the tumor tissue,collected during the operation,were detected.The correlations with other clinical features were studied.Results Compared with healthy tissue,TIDC in tumor tissue decreased significantly (10.58±3.18 vs.18.93±3.26,t= 18.877,P=0.000);VEGF (+) increased apparently (43.45 % vs.11.32%,χ2=26.131,P=0.000);MHC-Ⅱ positive DC was significantly decreased [(6.48±1.04)% vs.(12.57±2.57) %,t=22.615,P=0.000];CD54 positive DC was significantly decreased [(7.12±1.59)% vs.(12.81±2.81 )%,t= 18.144,P=0.000].When compared with the TNM staging of stage Ⅰ or Ⅱ patients,TIDC in patients with stageⅢ or Ⅳnumber density decreased significantly [(9.51±2.88) vs.(11.82±3.58),t=3.680,P=0.000].The positive rate of VEGF increased significantly (61.40% vs.20.41%, χ2= 18.126,P=0.000);MHC- Ⅱ positive DC rate was significantly decreased [ (7.83±1.05)% vs.(5.32±0.91) %,t=13.186,P=0.000];and CD54 positive DC rate decreased[ (6.26±1.01)% vs.(8.12±1.72) %,t= 6.900,P=0.000].When compared with patients with well differentiation,patients with low differentiation got a decrease in TIDC [(9.58±2.58) vs.(12.37±3.13),t= 4.941,P=0.000];a decrease in MHC-Ⅱ positive DC rate[ (6.01±1.09)% vs.(7.32±0.93) %,t=6.244,P=0.000];and a decrease in CD54 positive DC rate[(6.66±1.68)% vs.(7.94±1.58) %,t= 3.842,P=0.000].Patients with positive VEGF got decreased in TIDC,MHC- II positive DC rate and CD54 positive DC rate (P< 0.05).Conclusion The expression of TIDC in tumor tissues is low,which is mostly immature regulatory DC cells,while VEGF is highly expressed in tumor tissuesl.Both the TIDC and VEGF are associated with the worsen course of the disease. |
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