| 孙海涛,郝铁,杨卫红,等.激活素-α在脓毒症患者中的表达水平及临床意义[J].安徽医药,2018,22(9):1752-1754. |
| 激活素-α在脓毒症患者中的表达水平及临床意义 |
| The expression of activin-α in patients with sepsis and its clinical significance |
| 投稿时间：2017-02-15 |
| DOI： |
| 中文关键词: 激活素-α 脓毒症 病情严重度 危险因素 |
| 英文关键词: Activin-α Sepsis Severity Risk factors |
| 基金项目: |
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| 中文摘要: |
| 目的 探讨激活素-α在脓毒症患者中的表达水平及临床意义。方法 前瞻性收集2015年1月至2016年12月鞍山市中心医院收治的脓毒症患者127例,根据患者病情严重程度,将患者分为脓毒症组(n=21)、严重脓毒症组(n=68)和脓毒性休克组(n=38),主要观察指标包括激活素-α、降钙素原、C反应蛋白、APPACHEⅡ评分、序贯器官衰竭(SOFA)评分和乳酸。结果 脓毒症组、严重脓毒症组和脓毒性休克组患者激活素-α分别为(365.57±86.57)、(553.85±108.58)和(974.77±178.54) μg·L-1,三组比较差异有统计学意义(F=19.584,P=0.000)；降钙素原分别为(2.46±0.52)、(3.12±0.75)和(3.54±0.78) pg·L-1,三组比较差异有统计学意义(F=2.488,P=0.021),APPACHEⅡ评分分别为(13.57±4.38)、(18.48±5.22)和(24.89±7.12)分,三组比较差异有统计学意义(F=12.577,P=0.000)；SOFA评分分别为(4.12±1.28)、(7.88±2.09)和(11.83±4.25)分,三组比较差异有统计学意义(F=9.835,P=0.000)；乳酸分别为(2.45±0.54)、(3.98±0.78)和(5.12±1.53)mmol·L-1,三组比较差异有统计学意义(F=11.485,P=0.000)。多因素logistic回归分析显示激活素-α、APPACHEⅡ评分、SOFA评分和乳酸升高是脓毒症患者死亡的危险因素(P<0.05)。结论 激活素-α与脓毒症患者病情严重程度相关,在预测脓毒症患者临床预后中具有一定价值。 |
| 英文摘要: |
| Objective To investigate the expression of activin-α in patients with sepsis and its clinical significance.Methods From January 2015 to December 2016,7 patients with sepsis admitted to Anshan Central Hospital were prospectively collected.According to the severity of the disease,all patients were divided into sepsis group (n=21),severe sepsis group (n=68) and septic shock group (n=38).The primary outcomes included activin-α,procalcitonin C,C reactive protein,APPACHE Ⅱ score,SOFA score and lactate.Results The levels of activin-α in the sepsis group,severe sepsis group and septic shock group were(365.57±86.57),(553.85±108.58) and (974.77±178.54) μg·L-1;procalcitonin in the three groups were (2.46±0.52),(3.12±0.75) and (3.54±0.78) pg·L-1;APPACHEⅡ score were (13.57±4.38),(18.48±5.22) and (24.89±7.12).The SOFA score were (4.12±1.28), (7.88±2.09) and (11.83±4.25).The lactate were (2.45±0.54),(3.98±0.78) and (5.12±1.53) mmol·L-1.All these differences were statistically significant (P<0.05).Logistic regression analysis showed that an elevated activin-α,APPACHEⅡ score,SOFA score and lactate were risk factors of mortality in patients with sepsis.Conclusion Activin-α in patients with sepsis is positively associated with severity of the disease,and has a certain value in prediction the prognosis of patients with sepsis. |
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