| 李雪琴,方小正,卢正红,等.老年慢性心力衰竭患者血清25羟维生素D3水平与预后的相关性研究[J].安徽医药,2018,22(9):1776-1779. |
| 老年慢性心力衰竭患者血清25羟维生素D3水平与预后的相关性研究 |
| Association of serum 25-hydroxyvitamin D3 levels and the prognosis in elderly patients with chronic heart failure |
| 投稿时间：2017-10-17 |
| DOI： |
| 中文关键词: 心力衰竭 25羟维生素D3 预后 老年人 |
| 英文关键词: Chronic heart failure 25-hydroxyvitamin D3 Prognosis Aged |
| 基金项目:淮安市创新能力建设计划类—国际科技合作研究项目(HAC201622)老年慢性心力衰竭患者血清25羟维生素D3水平与预后的相关性研究李雪琴,方小正,卢正红,陈敏,谭娟,朱永芳 (南京医科大学附属淮安第一医院老年科,江苏 淮安 223300) |
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| 中文摘要: |
| 目的 观察老年慢性心力衰竭(HF)患者血清25羟维生素D3(25-OH-VitD3)水平与预后的相关性。方法 选择108例老年HF患者和68例老年健康体检者,记录两组人群的血清25-OH-VitD3水平及一般情况。根据25-OH-VitD3水平将HF组分为A组(≥50 nmol·L-1)和B组(＜50 nmol·L-1),比较两组在疗效方面的差异。结果 老年HF患者血清25-OH-VitD3和钙(Ca)水平低于对照组,收缩压、氨基N末端B型利钠肽前体(NT-proBNP)、甲状旁腺激素(PTH) 和抗酒石酸酸性磷酸酶5b(TRACP-5b)水平高于对照组,差异有统计学意义(P＜0.05)。A组25-OH-VitD3和Ca水平显著高于B组,NT-proBNP 、TRACP-5b和PTH水平显著低于B组,差异有统计学意义(P＜0.05)。A组抗高血压药物使用率及左室射血分数(LVEF)显著高于B组,而心功能分级、左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)及住院期间事件发生率显著低于B组,差异有统计学意义(P＜0.05)。logistic回归分析显示,25-OH-VitD3和LVEF是影响老年HF患者预后的独立危险因素,25-OH-VitD3与预后不良呈负相关(OR=0.798,95%CI=0.645～0.987,P=0.038)。结论 老年HF患者血清25-OH-VitD3水平降低,低25-OH-VitD3水平可能是影响老年HF患者预后的独立危险因素。 |
| 英文摘要: |
| Objective To investigate the association of serum 25-hydroxyvitamin D3 (25-OH-VitD3) levels and the prognosis in elderly patients with chronic heart failure (CHF).Methods 108 patients with CHF and 68 healthy controls were included,serum 25-OH-VitD3 levels and clinical data of who were recorded.The CHF patients were divided into group A (≥50 nmol·L-1) and group B (＜50 nmol·L-1) according to the levels of 25-OH-VitD3.The differences of risk factors for HF,past drug history,acute medications and the curative effect were compared between the two subgroups.Results The levels of serum 25-OH-VitD3 and calcium were lower,and the levels of systolic blood pressure, N-terminal pro b-type natriuretic peptide(NT-proBNP),parathyroid hormone(PTH) and tartrate resistant acid phosphatase 5b(TRACP-5b) were higher among the HF patients than in control group. The levels of serum 25-OH-VitD3 and calcuim were higher,the levels of serum NT-proBNP, TRACP-5b and PTH were lower in group Athan in group B. The antihypertensive drug usage and left ventricular ejection fraction(LVEF) were higher, cardiac function classification, left ventricular end diastolic diameter(LVEDD),left ventricular end systolic diameter(LVESD) and incidence of in-hospital events was lower in group Athan in group B.Logistic regression analysis suggested that serum 25-OH-VitD3 levels and LVEF were independent risk factors for predicting prognosis among CHF patients,serum 25-OH-VitD3 levels were inversely correlated with poor prognosis (OR=0.798,5%CI= 0.645-0.987,P=0.038).Conclusions Serum 25-OH-VitD3 levels were lower among elderly CHF patients,and low 25-OH-VitD3 levels might be an independent risk factor for poor prognosis in CHF patients. |
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