| 倪磊,陶扬洋,王华.银杏叶提取物注射液辅助治疗急性脑出血患者疗效及对患者细胞因子的影响[J].安徽医药,2018,22(9):1822-1824. |
| 银杏叶提取物注射液辅助治疗急性脑出血患者疗效及对患者细胞因子的影响 |
| Ginkgo Biloba Leaves Injection in the treatment of acute cerebral hemorrhage is the curative effect and the influence of cytokines |
| 投稿时间：2017-03-05 |
| DOI： |
| 中文关键词: 银杏叶提取物注射液 急性脑出血 疗效 细胞因子 |
| 英文关键词: Extract of ginkgo biloba leaves injection Acute cerebral hemorrhage Curative effect Cytokine |
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| 中文摘要: |
| 目的 探讨银杏叶提取物注射液辅助治疗急性脑出血患者疗效及对患者细胞因子的影响。方法 按照随机数字表法将收治的98例急性脑出血患者分为治疗组49例和对照组49例。对照组采用常规治疗,治疗组在常规治疗基础上结合银杏叶提取物注射液治疗。两组治疗疗程均为14 d。比较两组治疗疗效,治疗前后美国国立卫生研究院卒中量表(NIHSS)评分、日常生活能力量表(ADL)评分、血清炎症因子变化及不良反应情况。结果 治疗组治疗总有效率(93.88%)高于对照组(75.51%),差异有统计学意义(P<0.05)；两组NIHSS评分治疗后降低(P<0.05),治疗组治疗后低于对照组同期(P<0.05)；两组ADL评分治疗后增加(P<0.05),治疗组治疗后高于对照组同期(P<0.05)；两组出血量治疗后减少(P<0.05),治疗组治疗后低于对照组同期(P<0.05)；两组血清超敏C-反应蛋白(hs-CRP)、白细胞介素-6(IL-6)及肿瘤坏死因子(TNF-α)水平治疗后降低(P<0.05),治疗组治疗后低于对照组同期(P<0.05)；两组均未出现明显不良反应。结论 银杏叶提取物注射液辅助治疗急性脑出血患者疗效明显,且可降低血清细胞因子hs-CRP、IL-6及TNF-α水平,且用药安全性良好。 |
| 英文摘要: |
| Objective To investigate the effect of ginkgo biloba leaves extract injection in the treatment of acute cerebral hemorrhage and its influence of cytokines.Methods 98 cases of acute cerebral hemorrhage were randomly divided into treatment group and control group,each with 49 cases.Patients in the control group were treated with conventional therapy,while the treatment group was treated with extract of ginkgo biloba leaves injection.The two groups were treated for 14 d.The therapeutic effects of the two groups were compared before and after treatment,NIHSS score,ADL score,serum inflammatory factors and adverse reactions were observed before and after treatment.Results The treatment group total efficiency of (93.88%) was higher than control group (75.51%) (P<0.05).The NIHSS scores of the two groups after treatment decreased (P<0.05),and treatment group after treatment lower than in the control group(P<0.05);the ADL scores of the two groups increased after treatment (P<0.05),the treatment group after treatment was higher than that of the control group(P<0.05);two groups of blood loss after treatment decreased (P<0.05),the treatment group after treatment than the control group(P<0.05);the two groups of serum high sensitive C Reaction Protein (hs-CRP),interleukin-6 (IL-6),and tumor necrosis factor-alpha (TNF-α) levels decreased after treatment (P<0.05),treatment group was lower than the control group after treatment (P<0.05);two groups of liver and kidney function,electrocardiogram,blood routine,urine routine were not abnormal,and no obvious adverse drug reaction.Conclusion Ginkgo biloba leaves injection in the treatment of acute cerebral hemorrhage is the curative effect obvious,which can reduce the levels of serum cytokines hs-CRP,IL-6 and TNF-α. |
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