| 程锦绣,陆继芳,李玥欣,等.尿毒清颗粒对腹膜透析患者临床疗效的影响[J].安徽医药,2018,22(10):1997-2000. |
| 尿毒清颗粒对腹膜透析患者临床疗效的影响 |
| Effect of niaoduqing granules on the clinical efficacy in patients undergoing peritoneal dialysis |
| 投稿时间：2017-04-12 |
| DOI： |
| 中文关键词: 肾功能衰竭,慢性 腹膜透析 红细胞生成素 甲状旁腺素 瘦素 治疗结果 尿毒清 |
| 英文关键词: Kidney failure,chronic Peritoneal dialysis Erythropoietin Parathyroid hormone Leptin Treatment outcome Niaoduqing |
| 基金项目:张家口市科技攻关计划项目(1621067D) 尿毒清颗粒对腹膜透析患者临床疗效的影响程锦绣,陆继芳,李玥欣,楚德英,王琳琳,刘翠兰,刘圣君,刘华 (河北北方学院附属第一医院,河北 张家口 075000) 尿毒清颗粒对腹膜透析患者临床疗效的影响程锦绣,陆继芳,李玥欣,楚德英,王琳琳,刘翠兰,刘圣君,刘华 Effect of niaoduqing granules on the clinical efficacy in patients undergoing peritoneal dialysis CHENG Jinxiu,LU Jifang,LI Yuexin,CHU Deying,WANG Linlin,LIU Cuilan,LIU Shenjun,LIU Hua |
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| 中文摘要: |
| 目的 观察尿毒清对腹膜透析(PD)患者临床疗效的影响。 方法 选择北方学院附属第一医院2010年1月至2015年6月收治的慢性肾功能衰竭接受PD患者70例,采用随机数字表法分为治疗组和对照组,每组35例。两组均进行常规PD,对照组给予促红素纠正贫血、降血压等基础治疗,治疗组在基础治疗同时给予尿毒清颗粒4次/天,于6、12、18时各服5 g及22时服10 g,共治疗8周。抽取治疗前后清晨空腹静脉血,采用全自动生化分析仪测定血肌酐(SCr)、尿素氮(BUN)、血红蛋白(Hb)、白蛋白(Alb)、三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、钙(Ca)、磷(P)、同型半胱氨酸(Hcy),采用放射免疫分析法测定甲状旁腺激素(iPTH)、瘦素(LP)。结果 治疗前两组各观察指标均差异无统计学意义(P>0.05)。治疗后,治疗组HDL-C升高,TG、TC、LDL-C降低,与治疗前比较均差异有统计学意义(P<0.05),而对照组与治疗前无明显变化；两组SCr、BUN均降低,Hb、Alb均升高。治疗组治疗后BUN、TG、TC、P、iPTH、Hcy和LP低于对照组,Hb、Alb、HDL-C、Ca高于对照组,均差异有统计学意义(P<0.05)；其中治疗组BUN(17.52±4.71)mmol·L－1、P(1.22±0.51)mmol·L－1、iPTH(21.76±8.74)ng·L－1、Hcy(11.23±2.47)μmol·L－1均低于对照组(P<0.01),Hb、Alb高于对照组(P<0.01)。 结论 尿毒清可改善PD患者脂质代谢、降低高磷血症及高Hcy血症、减低iPTH及LP水平,改善患者生存质量。 |
| 英文摘要: |
| Objective To explore the effect of niaoduqing granules on the clinical efficacy in patients undergoing peritoneal dialysis (PD). Methods A total of 70 patients with chronic renal failure (CRF) who were admitted to The First Hospital Affiliated to Hebei North University from January 2010 to June 2015 for PD were included in the study and randomized into the treatment group and the control group,35 patients in each group.The patients in the two groups were given routine PD.The patients in the control group were given erythropoietin for anemia correction,blood pressure reduction,and other basic treatments.On the above basis,the patients in the treatment group were given additional niaoduqing granules,4 times/d,5 g at 6,2,and 18 o′clock,and 10 g at 22 o′clock,for 8 weeks.The morning fasting venous blood before and after treatment was collected.The full automatic biochemical analyzer was used to detect serum creatinine (SCr),blood urea nitrogen (BUN),hemoglobin (Hb),albumin (Alb),triacylglycerol (TG),total cholesterol (TC),high density lipoprotein cholesterol (HDL-C),low density lipoprotein cholesterol (LDL-C),calcium (Ca),phosphorus (P),and homocysteine (Hcy).Radioimmunoassay (RIA) was used to detect parathormone (iPTH) and leptin (LP). Results The difference in the observation indicators before treatment between the two groups was not statistically significant (P>0.05).After treatment HDL-C in the treatment group was significantly elevated,while TG,TC,and LDL-C were significantly reduced when compared with before treatment (P<0.05).HDL-C,TG,TC,and LDL-C after treatment in the control group were not significantly changed when compared with before treatment.Scr and BUN in the two groups were significantly reduced after treatment,while Hb and Alb were significantly elevated.After treatment BUN,TG,TC,P,iPTH,Hcy,and LP in the treatment group were significantly lower than those in the control group,while Hb,Alb,HDL-C,and Ca were significantly higher than those in the control group (P<0.05),among which BUN(17.52±4.71)mmol·L-1,P(1.22±0.51)mmol·L-1,iPTH(21.76±8.74)ng·L-1,and Hcy(11.23±2.47)μmol·L-1 in the treatment group were significantly lower than those in the control group (P<0.01),while Hb and Alb were significantly higher than those in the control group (P<0.01). Conclusions Niaoduqing granules in the treatment of PD can improve the lipid metabolism,reduce hyperphosphatemia and hyperhomocysteinemia,lower iPTH and LP levels,and enhance the quality of lives of the patients. |
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