| 邹国华,代春.微血管侵犯对单发性小肝癌患者预后的影响[J].安徽医药,2018,22(11):2119-2122. |
| 微血管侵犯对单发性小肝癌患者预后的影响 |
| Effect of microvascular invasion on the prognosis of patients with single small hepatocellular carcinoma afterresection |
| 投稿时间：2017-05-11 |
| DOI： |
| 中文关键词: 小肝癌 单发 微血管侵犯 生存率 复发 影响因素 预后 |
| 英文关键词: Small hepatocellular carcinoma Single Microvascular invasion Survival rate Recurrence Influence factor Prognosis |
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| 中文摘要: |
| 目的 探讨微血管侵犯对术后单发性小肝癌患者预后及生存率的影响。方法 选择达州职业技术学院附属医院2011年1月至2014年1月期间接受手术治疗的80例单发性小肝癌患者,对其临床资料进行回顾性分析,有微血管侵犯的35例为观察组,无微血管侵犯的45例为对照组。对所有患者进行术后跟踪随访3年,比较两组患者临床病理特征,无瘤生存率和总生存率,采用COX风险回归模型对影响生存率的因素进行分析。结果 两组患者在年龄、性别、是否乙肝感染、是否肝硬化、Child-pugh分级、甲胎蛋白、丙氨酸氨基转移酶、总胆红素水平和肿瘤直径均差异无统计学意义(P>0.05)。观察组患者3年无瘤生存率(60.00% vs.75.56%)和总生存率(65.71% vs.77.78%)均略低于对照组患者,但差异无统计学意义(均P>0.05)。观察组患者3年内的复发率为34.29%,明显高于对照组患者的13.33%,差异有统计学意义(χ2=4.956,P=0.026)。COX风险回归模型显示,微血管侵犯和肿瘤直径大小是影响患者术后生存的危险因素。结论 单发性小肝癌术后患者发生微血管侵犯不利于患者的预后,可能增加患者复发概率,降低患者生存率,应在临床治疗中慎重对待。 |
| 英文摘要: |
| Objective To explore the effect of microvascular invasion on the prognosis and survival of patients with single small hepatocellular carcinoma after resection.Methods Eighty patients with single small hepatocellular carcinoma undergoing surgical treatment from January 2011 to January 2014 in the Affiliated Hospital of Dazhou Vocational and Technical College were enrolled in the study,whose clinical data were retrospectively analyzed.Among 80 patients,35 cases with microvascular invasion were selected as the observation group,and the other 45 cases without microvascular invasion were selected as the control group.All patients were followed up for 3 years.The clinical pathological characteristics,disease-free survival and overall survival were compared between the two groups,and the Cox proportional hazards regression model was used to analyze the possible influence factors that affecting survival.Results The results of clinical and pathological characteristics in both groups showed that there were no statistically significant differences in age,gender,HBV infection,liver cirrhosis,Child-Pugh score,AFP,ALT,total bilirubin level and the tumor diameter between the two groups (P>0.05).The three-year disease-free survival rate (60.00% vs.75.56%) and overall survival rate (65.71% vs.77.78%) in the observation group were slightly lower than those in the control group,but the differences were not statistically significant (P>0.05).The recurrence rate in the observation group (34.29%) was significantly higher than that in the control group (13.33%);the difference was statistically significant (χ2=4.956,P=0.026).The COX proportional hazards regression model showed that microvascular invasion and tumor size were the risk factors for postoperative survival.Conclusion Microvascular invasion is not conducive to the prognosis of patients with single small hepatocellular carcinoma after surgery,which may increase the risk of tumor recurrence and reduce the survival rate of patients.Therefore,it needed to be treated with caution clinically. |
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