| 王霜,杨正国,杨波,等.糖尿病肾病患者血清三叶因子3水平的变化及其临床意义分析[J].安徽医药,2018,22(11):2199-2201. |
| 糖尿病肾病患者血清三叶因子3水平的变化及其临床意义分析 |
| Changes of serum TFF3 level in DN patients and its clinical significance |
| 投稿时间：2016-11-18 |
| DOI： |
| 中文关键词: 糖尿病肾病 三叶因子3 炎性因子 血脂 相关分析 |
| 英文关键词: Diabetic nephropathy Three leaf factor 3 Inflammatory cytokines Blood lipid Correlation analysis |
| 基金项目: |
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| 摘要点击次数: 1913 |
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| 中文摘要: |
| 目的 观察糖尿病肾病(DN)患者血清三叶因子3(TEF3)水平的变化,并分析其临床意义。方法 回顾性分析2015年3月至2016年8月在解放军第一四八医院接受治疗的45例DN患者的临床资料,同期选取院内体检正常者40例为对照组。比较两组血清TEF3、炎性因子和血脂水平的差异,分析DN患者TEF3水平与炎性因子和血脂水平的相关性。结果 DN组患者的TEF3、白细胞介素-18(IL-18)、白细胞介素-6(IL-6)和超敏C-反应蛋白(hs-CRP)水分别为(15.86±2.34)μg·L-1、(50.16±8.98)mg·L-1、(13.96±2.08)mg·L-1、(7.83±0.73)mg·L-1,明显高于对照组,差异有统计学意义(t=-18.608、-17.817、-21.374、-53.140,P<0.001)；DN组患者的三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白(LDL-C)和同型半胱氨酸(Hcy)水平分别为(2.46±0.51)、(4.95±1.03)、(2.46±0.55) mmol·L-1和(30.01±5.04)μmol·L-1,明显高于对照组(t=-6.613、-7.692、-7.924、-15.331,P<0.001),高密度脂蛋白(HDL-C)水平低于对照组(t=3.974,P<0.001)；DN患者的TEF3水平与IL-18、IL-6、hs-CRP、TG、TC、LDL-C和Hcy水平正相关(r=0.465、0.398、0.413、0.382、0.402、0.369、0.352,P=0.012、0.027、0.035、0.019、0.033、0.041、0.025),而与HDL-C水平负相关(r=-0.422,P=0.030)。结论 DN患者的TEF3水平较高,且与患者的血清炎性因子和血脂等水平密切相关,可作为临床监测的重要指标之一。 |
| 英文摘要: |
| Objective To observe the changes of serum level of three leaf factor 3 (TEF3) in patients with diabetic nephropathy (DN) and to analyze its clinical significance.Methods The clinical data of DN patients who received treatment in The 148th Hospital of PLA from March 2015 to August 2016 were analyzed retrospectively.The clinical data of healthy physical examinees in the same hospital during the same period were selected as the control group.The differences of serum TEF3,inflammatory cytokines and serum lipid levels were compared between the two groups,and the correlation between serum TEF3 levels and inflammatory cytokines as well as serum lipid levels in patients with DN were analyzed.Results The levels of TEF3,interleukin-18 (IL-18),interleukin-16(IL-16) and high sensitive Creactive protein (hs-CRP) in the DN group were (15.86±2.34) μg·L-1,(50.16±8.98) mg·L-1,(13.96±2.08)mg·L-1,and (7.83±0.73) mg·L-1,respectively,which were significantly higher than those in the control group;the differences were statistically significant (t=-18.608,-17.817,-21.374,-53.140,P<0.001).The levels of triglyceride (TG),total cholesterol (TC),low density lipoprotein (LDL-C) and homocysteine (Hcy) in the DN group were (2.46±0.51) mmol·L-1,(4.95±1.03)mmol·L-1,(2.46±0.55) mmol·L-1,and (30.01±5.04) μmol·L-1,respectively,which were significantly higher than those in the control group (t=-6.613,-7.692,-7.924,-15.331,P<0.001).High density lipoprotein (HDL-C) level in the DN group was lower than that in the control group (t=3.974,P<0.001).There was a positive correlation between TEF3 level and IL-18,IL-16,hs-CRP,TG,TC,LDL-C and Hcy levels of DN patients (r=0.465,0.398,0.413,0.382,0.402,0.369,0.352;P=0.012,0.027,0.035,0.019,0.033,0.041,0.025),and there was a negative correlation between TEF3 level and the level of HDL-C (r=-0.422,P=0.030).Conclusion The level of TEF3 in patients with DN is higher,and is closely related with the levels of serum inflammatory cytokines and blood lipid of DN patients,which can be used as one of the important indicators of clinical monitoring. |
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