| 王慧丽,范晓芳,张琳.肌壁大部切除-子宫重建术联合左炔诺孕酮宫内缓释系统治疗中重度子宫腺肌病的疗效及对卵巢功能的影响[J].安徽医药,2018,22(12):2375-2378. |
| 肌壁大部切除-子宫重建术联合左炔诺孕酮宫内缓释系统治疗中重度子宫腺肌病的疗效及对卵巢功能的影响 |
| Efficacy of major uterine wall resection-reconstruction of the uterus combined with mirena in the treatment of moderate and severe adenomyosis and the effects on ovarian function |
| 投稿时间：2017-09-01 |
| DOI： |
| 中文关键词: 肌壁大部切除 子宫重建术 左炔诺孕酮宫内缓释系统 子宫腺肌病 卵巢功能 |
| 英文关键词: Major uterine wall resection Uterine reconstruction Mirena Adenomyosis Ovarian function |
| 基金项目: |
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| 中文摘要: |
| 目的 观察肌壁大部切除-子宫重建术(MURU)联合左炔诺孕酮宫内缓释系统(MIR)治疗中重度子宫腺肌病的疗效及其对卵巢功能的影响。 方法 选取2014年1月至2016年1月在上海市普陀区妇婴保健院治疗的中、重度子宫肌腺病患者60例,采用随机数字表法分为观察组和对照组,各30例。观察组行MURU+MIR,对照组行MURU+术后注射醋酸亮丙瑞林微球(GnRHa)。分别于术前、术后6月、12月时评估患者的痛经症状、经量评分、血清糖类抗原125(CA125)、子宫体积、血清抗缪勒氏管激素(AMH)值,对上述指标进行两组间以及术前术后比较。 结果 观察组与对照组术后6月、12月痛经评分、经量评分、CA125与子宫体积均比术前降低(均P＜0.05)；两组术后6月、12月痛经评分均为0分,观察组术后6月、12月的经量评分、CA125与子宫体积均显著低于对照组(均P＜0.05)。两组自身术前与术后6月、12月血清AMH比较,均差异无统计学意义(均P＞0.05)。观察组血清AMH术前、术后6月、术后12月分别与对照组血清AHM术前、术后6月、术后12月比较,均差异无统计学意义(均P＞0.05)。 结论 MURU联合MIR治疗中重度子宫腺肌病的疗效好,且近期不影响卵巢功能,值得推广。 |
| 英文摘要: |
| Objective To explore the efficacy of major uterine wall resection-reconstruction of the uterus (MURU) combined with mirena (MIR) in the treatment of moderate and severe adenomyosis and the effects on ovarian function. Methods 60 patients with moderate and severe adenomyosis from January 2014 to January 2016 in Shanghai Putuo District Maternal and Infant Health Hospital were selected and randomly divided into observation group and control group.Observation group (30 cases) was treated with MURU combined with MIR,and control group (30 cases) was treated with MURU combined with GnRHa.Dysmenorrhea score,menstrual blood volume score,serum carbohydrate antigen 125 (CA125) and uterine volume before and after treatment were observed and compared between groups.Results The dysmenorrhea score,menstrual blood volume score,CA125 and uterine volume in the observation group and the control group were lower than those before treatment (P＜0.05).Two groups of dysmenorrhea scores were 0 points after treatment,the scores of menstrual blood volume score,CA125 and uterine volume were lower in the observation group than those in the control group after treatment.There was no significant difference in serum AMH between the two groups before and after operation (P＞0.05).The serum AMH of preoperative,postoperative 6 months and postoperative 12 months were compared with the control group of serum AHM before and after surgery,and the differences were not statistically significant (P＞0.05). Conclusion MURU combined with MIR in the treatment of moderate and severe adenomyosis is effective,with no effects on ovarian function in short time,which is worthy of promotion. |
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