| 鲁海燕,张喜平.香菇多糖对新辅助化疗后乳腺癌患者免疫功能及淋巴细胞的影响[J].安徽医药,2018,22(12):2427-2430. |
| 香菇多糖对新辅助化疗后乳腺癌患者免疫功能及淋巴细胞的影响 |
| Effect of lentinan on infiltrating lymphocytes of tumor tissue and peripheralblood in breast cancer patients undergoing neoadjuvant chemotherapy |
| 投稿时间：2017-02-14 |
| DOI： |
| 中文关键词: 乳腺癌 香菇多糖 淋巴细胞浸润 新辅助化疗 |
| 英文关键词: Breast cancer Lentinan Lymphocyte infiltration Neoadjuvant chemotherapy |
| 基金项目: |
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| 摘要点击次数: 1949 |
| 全文下载次数: 639 |
| 中文摘要: |
| 目的 探讨香菇多糖对新辅助化疗后乳腺癌患者免疫功能及淋巴细胞的影响。 方法 自2015年1月至2016年10月,前瞻性收集内蒙古医科大学附属医院收治的接受新辅助化疗的乳腺癌患者88例,采用随机对照的方式将其分为观察组(44例)和对照组(44例)。两组患者治疗方法相同,观察组联合应用香菇多糖,所有患者均新辅助化疗后手术切除肿瘤组织并留取肿瘤组织标本,观察肿瘤组织及外周血CD4+T细胞、CD8+T细胞、CD4+/CD8+比例以及血清白细胞介素-6(IL-6)、白细胞介素-10(IL-10)、转化生长因子-β1(TGF-β1)浓度。 结果 治疗后,观察组肿瘤组织微环境CD4+T细胞明显低于对照组(21.56%±5.08% 比 23.95%±5.17%,t=2.187,P=0.031)；CD8+T细胞高于对照组(29.52%±3.51% 比 27.47%±3.68%,t=2.673,P=0.009)；CD4+/CD8+T细胞比例低于对照组(0.72±0.12比 0.86±0.14,t=5.036,P=0.000)。外周血CD4+T细胞水平明显增加(28.57%±4.32% 比 26.23%±4.12%,t=2.600,P=0.011)；CD4+/CD8+T细胞比例明显增加(0.84±0.15比 0.76±0.13,t=2.673,P=0.009)。外周血IL-6浓度明显增高[(14.56±4.79) 比(11.45±4.48) ng·L-1,t=3.145,P=0.002)]；IL-10浓度明显降低[(11.34±3.37) 比(13.46±3.41) ng·L-1,t=2.933,P=0.004)]；TGF-β1浓度明显降低[(15.14±4.69) 比 (17.67±4.53) μg·L-1,t=2.290,P=0.024)]。结论 香菇多糖有助于提高新辅助化疗后乳腺癌患者免疫功能,改善肿瘤组织微环境中免疫状态。 |
| 英文摘要: |
| Objective To investigate the effect of lentinan on infiltrating lymphocytes in the microenvironment of breast cancer patients with neoadjuvant chemotherapy. Methods From January 2015 to October 2016,8 breast cancer patients admitted to our hospital received neoadjuvant chemotherapy and were randomly assigned into a study group (44 cases) and a control group (44 cases).Basic treatment were the same in two groups and patients in the study group received lentinan injection.After neoadjuvant chemotherapy,surgical resection were performed in all patients and tumor tissue were collected.The CD4+T cells,CD8+T cells and the proportion of CD4+/CD8+T cells in tumor tissue and peripheral blood and serum level of IL-6,IL-10 and TGF-β1 were observed.Results When compared with control group after the treatment,patients in the study group showed significantly decrease of CD4+T cells (21.56 %± 5.08 % vs.23.95%±5.17%, t=2.187,P=0.031);increase of CD8+ T cell (29.52%±3.51% vs.27.47%±3.68%,t=2.673,P=0.009) and decrease of the proportion of CD4+/CD8+T cells,respectively (0.72±0.12 vs.0.86±0.14,t=5.036,P= 0.000).Moreover,in peripheral blood,patients in the study group got an elevated post-operative level of CD4+T cells (28.57%±4.32% vs.26.23%±4.12%,t=2.600,P=0.011),a higher level of CD4+/CD8+T (0.84±0.15 vs. 0.76±0.13,t=2.673,P=0.009),an increase in IL-6 level (14.56±4.79 vs.11.45±4.48 ng·L-1,t =3.145,P=0.002),a decrease in IL-10[(11.34±3.37) vs. (13.46±3.41) ng·L-1,t=2.933,P=0.004)],and a decrease in TGF-β1 [(15.14±4.69) vs.(17.67±4.53) μg·L-1,t=2.290,P=0.024)].Conclusions Lentinan is helpful to improve the immune status in the microenvironment and the total immune function in patients with breast cancer who underwent neoadjuvant chemotherapy. |
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