| 张小玲.预防性口服布洛芬对早产儿动脉导管未闭的临床价值[J].安徽医药,2018,22(12):2457-2459. |
| 预防性口服布洛芬对早产儿动脉导管未闭的临床价值 |
| Clinical value of prophylatic use of ibuprofen on premature patent ductus arteriosus:a clinical research |
| 投稿时间：2017-04-25 |
| DOI： |
| 中文关键词: 布洛芬 早产儿 动脉导管未闭 |
| 英文关键词: Ibuprofen In preterm infants Closure of patent ductus arteriosus |
| 基金项目: |
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| 摘要点击次数: 1920 |
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| 中文摘要: |
| 目的 评价预防性口服布洛芬治疗早产儿动脉导管未闭(PDA)的疗效与安全性。 方法 选取西安高新医院新生儿科2013年3月至2016年3月收治的153例胎龄小于30周的早产儿作为研究对象,采用随机数字表法分为预防性治疗组76例和常规治疗组77例。预防性治疗组,出生后24 h内给予口服首剂布洛芬10 mg·kg-1,每隔24 h后口服第二、三剂布洛芬5 mg·kg-1。常规治疗组在出生后第3天对超声证实存在PDA的患儿给予相同剂量的布洛芬口服。出生后第3天,第7天分别行心脏超声检查,抽外周血查肾功及血常规,并监测有无不良反应,两组进行观察比较。 结果 预防性治疗组在出生后第3天及出生后第7天PDA关闭率(73.7%、78.9%)均高于常规治疗组(55.8%、63.2%),差异有统计学意义(P<0.05)；预防性治疗组在出生后第3天及出生后第7天的尿素氮及肌酐水平与常规治疗组相比,差异无统计学意义(P>0.05)；在近期并发症如肾功损害、尿少、坏死性小肠结肠炎、重度脑室内出血发生率方面两组差异无统计学意义(P>0.05)。 结论 口服布洛芬能够有效关闭早产儿动脉导管,不增加近期不良反应发生率,安全性好。 |
| 英文摘要: |
| Objective To evaluate the efficacy and safety of prophylactic oral ibuprofen in the treatment of premature infants with patent ductus arteriosus (PDA). Methods 153 premature infants with gestational age less than 30 weeks from March 2013 to March 2016 in our hospital were selected and randomly divided into prophylactic treatment group (76) and routine treatment group 77p.Within in 24 h after birth,rophylactic treatment group were given orally the first dose of ibuprofen 10 mg·kg-1 and every 24 h after oral second dose of ibuprofen 5 mg·kg-1.The routine treatment group was given the same dose of ibuprofen orally for children confirmed by ultrasonography with PDA on the 3rd day after birth.The 3rd day and the 7th day after the birth,the cardiac ultrasound examination,the pumping peripheral blood check kidney work,the blood routine,and adverse reactions were monitored respectively and,two groups carries on the observation comparison. Results The closure rate of arterial catheter in the 3rd day and the 7th days after birth of the prevention group was higher than that of the conventional treatment group (73.7% vs.55.8%,78.9% vs.63.2%,P＜0.05).The level of urea nitrogen and creatinine in the 3rd day after birth and the 7th day of the group was compared with the conventional treatment group.There was no statistically significant difference (P> 0.05).There was no statistically significant difference between the two groups in recent complications such as renal impairment,less urine,necrotizing enterocolitis and severe intraventricular hemorrhage (P>0.05). ConclusionsOral ibuprofen can effectively close patent ductus arteriosus in premature infants,without increasing the incidence of adverse reactions in the near future,and with safety. |
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