| 李文翠,高波,张吉才.甲状腺乳头状癌组织中G-蛋白偶联受体5和组织蛋白酶D的表达及临床意义[J].安徽医药,2019,23(1):19-21. |
| 甲状腺乳头状癌组织中G-蛋白偶联受体5和组织蛋白酶D的表达及临床意义 |
| The expression of LGR5 and Cath Din thyroid papillary carcinoma and their clinical significance |
| 投稿时间：2017-11-18 |
| DOI： |
| 中文关键词: 甲状腺肿瘤 受体,G-蛋白偶联 组织蛋白酶D 肿瘤侵润 肿廇转移 |
| 英文关键词: Thyroid neoplasms Receptors,g-protein-coupled Cathepsin D Neoplasm invasiveness Neoplasm metastasis |
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| 中文摘要: |
| 目的 分析甲状腺乳头状癌组织与癌旁组织中G-蛋白偶联受体5(LGR5)及组织蛋白酶D(Cath D)的表达与各临床病理因素之间的关系。方法 采用免疫组化的方法检测LGR5和Cath D在67例甲状腺乳头状癌与癌旁正常甲状腺组织中的表达,分析它们的表达与性别、年龄、肿瘤大小、淋巴结阳性、局部包膜侵犯、原发肿瘤区域淋巴结远处转移(TNM)分期等临床病理因素的关系。结果 甲状腺乳头状癌和癌旁正常甲状腺组织中LGR5的阳性表达率分别为62.69%(42/67)、2.99%(2/67),Cath D的阳性表达率分别为70.15%(47/67)、4.48%(3/67),甲状腺乳头状癌组织中LGR5和Cath D阳性表达率均明显高于癌旁正常组织(P<0.05)。在有淋巴结转移和局部包膜侵犯组织中,LGR5、Cath D阳性表达率明显高于无淋巴结转移者和无局部侵犯者(P<0.05)；不同肿瘤大小、不同TNM分期的病人甲状腺乳头状癌组织中LGR5及Cath D的阳性表达率均差异有统计学意义(P<0.05)；LGR5及Cath D的阳性表达率与病人年龄、性别无关(P>0.05)。结论 甲状腺乳头状癌组织中LGR5和Cath D的高表达与肿瘤的侵袭和转移密切相关。 |
| 英文摘要: |
| Objective To study the relationship between the expression of LGR5 and Cath Din papillary thyroid carcinoma and clinicopathological parameters.Methods The expression of LGR5 and Cath Dwere detected in 67 cases of thyroid papillary carcinoma and paired adjacent normal thyroid tissues by immunohistochemical staining,to analyze the relationship between LGR5 and Cath Dpositive expression and different clinical pathological parameters such as gender,age,tumor size,lymph node metastasis,local invasion,TNM staging.Results The positive expression rates of LGR5 in papillary thyroid carcinoma and adjacent normal thyroid tissues were 62.69% (42/67) and 2.99% (2/67),respectively.The positive expression rates of Cath Dwere 70.15% (47/67) and 4.48% (3/67),respectively.The positive expression rates of LGR5 and Cath Din papillary thyroid carcinoma were significantly higher than those in adjacent normal tissues (P<0.05).The positive expression rate of LGR5 and Cath Din patients with local invasion and lymph node metastasis was significantly higher than those without local invasion and lymph node metastasis (P<0.05).The positive expression rates of LGR5 and Cath Din patients of different genders and ages were compared,some differences were not statistically significant (P>0.05).Conclusion High expression of LGR5 and Cath Din papillary thyroid carcinoma is closely related to tumor invasion and metastasis |
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