| 周萍,焦瑞宝,章文,等.慢性肾脏病病人胃蛋白酶原Ⅰ、Ⅱ检测的意义[J].安徽医药,2019,23(1):66-68. |
| 慢性肾脏病病人胃蛋白酶原Ⅰ、Ⅱ检测的意义 |
| Significance of pepsinogen Ⅰ and Ⅱ in patients with chronic kidney disease |
| 投稿时间：2017-03-11 |
| DOI： |
| 中文关键词: 肾功能不全,慢性 胃蛋白酶原类 肌酸酐 酶联免疫吸附测定 |
| 英文关键词: Renal insufficiency,chronic Pepsinogens Creatinine Enzyme-linked immunosorbent assay |
| 基金项目: |
|
| 摘要点击次数: 1840 |
| 全文下载次数: 513 |
| 中文摘要: |
| 目的 探讨慢性肾脏病(CKD)病人蛋白酶原Ⅰ、Ⅱ检测结果对肾功能减退程度评估的价值。方法 2015年10月至2016年3月铜陵市人民医院收治的117例慢性肾脏病病人,根据肾功能减退程度分四组；对照组选取84例健康者。以酶联免疫方法检测各组样本的胃蛋白酶原Ⅰ(PGⅠ)、胃蛋白酶原Ⅱ(PGⅡ)水平,肌氨酸氧化酶法检测血肌酐(SCr)水平,做对比分析。结果 慢性肾脏病各组病人的PGⅠ水平(μg/L)(251.62±96.36、308.58±101.89、379.54±117.09、401.59±115.42)、PGⅡ水平(μg/L)(25.85±16.17、25.81±15.79、23.52±15.04、31.31±21.57)均明显高于对照组(P<0.05)；随着肾功能减退程度的增加,PGⅠ的水平逐渐增高,PGⅠ与SCr呈明显正相关性(r=0.6180,P<0.05)；CKD各组之间PGⅡ水平的差异无统计学意义(P>0.05),PGⅡ与SCr呈正相关性(r=0.2051,P>0.05)。结论 胃功能指标PGⅠ、PGⅡ的检测结果有助于慢性肾脏病肾功能损伤程度的监测和评价,特别是在肾功能损伤的早期阶段。 |
| 英文摘要: |
| Objective To investigate the value of the detection results of the Pepsinogen Ⅰ and Ⅱ in the evaluation of renal function in the patients with chronic kidney disease (CKD).Methods 117 cases of patients with chronic kidney disease were divided into 4 groups according to the degree of impairment of renal function 84 healthy subjects were also selected as control group.The ELISA was applied to measure the original 1 (PG Ⅰ),pepsinogen Ⅱ (PG Ⅱ) in each sample,and the serum creatinine (SCr) level was tested by Muscle ammonia oxidase method,which were analyzed by SPSS.Results The results of PG Ⅰ levels(μg/L) (251.62±96.36,308.58±101.89,379.54±117.09,401.59±115.42) and PG Ⅱ levels(μg/L)(25.85±16.17,25.81±15.79,23.52±15.04,31.31±21.57) in patients with chronic kidney disease group Ⅱ were significantly higher than the control group (P<0.05).With the increase of the degree of renal dysfunction,PG Ⅰ levels gradually increased.PG Ⅰ was significantly correlated with SCr (r=0.6180,P<0.05).There was no significant difference in the level of PG Ⅱ of each groups of CKD (P>0.05).PG Ⅱ is positively related to SCr (r=0.2051,P>0.05).Conclusion The results of PG and PG Ⅱ are helpful to the monitoring and evaluation of renal function damage in chronic kidney disease,especially in the early stage of renal injury. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
