| 税全,李毅,郭勇.H型高血压病人心率变异性与临床特征分析[J].安徽医药,2019,23(1):99-102. |
| H型高血压病人心率变异性与临床特征分析 |
| Analysis of heart rate variability and clinical features in patients with Htype hypertension |
| 投稿时间：2017-05-31 |
| DOI： |
| 中文关键词: 高血压 半胱氨酸 颈动脉内膜中膜厚度 肾小球滤过率 心率变异性 靶器官功能 |
| 英文关键词: Hypertension Cysteine Carotid intima-media thickness Glomerular filtration rate Heart rate variability Target organ function |
| 基金项目:四川省达州市卫生局科研基金(J201503012488) H型高血压病人心率变异性与临床特征分析税全1,李毅2,郭勇2(1.达州市中心医院,住院部心电图室,四川 达州 635000;2.达州市中心医院心内科,四川 达州 635000) |
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| 中文摘要: |
| 目的 探讨H型高血压病人心率变异性与临床特征。方法 前瞻性收集四川省达州市中心医院2016年1月至2017年3月收治的高血压病人147例,根据病人入院时同型半胱氨酸水平,将病人分为观察组63例(H型高血压,同型半胱氨酸≥10 mmol/L)和对照组84例(同型半胱氨酸<10 mmol/L)。观察两组病人24 h心率变异性,同时分析心率变异性与病人靶器官功能损伤的相关性。结果 与对照组比较,观察组病人24 h全部窦性R-R间期标准差(SDNN)显著降低[(89.75±18.28)比(104.38±22.71) ms,P=0.000]；每5分钟窦性R-R间期均值的标准差(SDANN)显著降低[(92.47±13.47)比(101.72±15.28) ms,P=0.000]；24 h连续5 min窦性R-R间期标准差的均值(SDNN-Index)显著降低[(33.29±8.73)比(40.67±10.38) ms,P=0.000]；所有临近窦性R-R间期差值的均方根(rMSSD)显著降低[(27.48±9.12)比(31.84±10.55) ms,P=0.010]；所有相邻两个窦性R-R间期差值大于50 ms的心搏数占全部心搏数的百分比(PNN50)显著降低[(9.21±5.38)比(15.38±8.91)%,P=0.000]；颈动脉内膜中膜厚度显著增加[(0.97±0.12)比(0.89±0.14)mm,P=0.000]；左室质量指数显著增加[(132.48±21.48)比(122.48±22.72) g/m2,P=0.008]。SDNN、SDNN-Index和PNN50与颈动脉内膜中膜厚度显著负相关(P<0.05),SDNN、SDANN、SDNN-Index、rMSSD和PNN50与左室质量指数显著负相关(P<0.05)。结论 H型高血压病人心率变异性显著降低,与靶器官功能损害有关。 |
| 英文摘要: |
| Objective To investigate the heart rate variability and clinical features in patients with Htype hypertension.Methods 147 patients with hypertension in our hospital were prospectively collected and assigned into an observation group(H type hypertension,homocysteine≥10 mmol/L)or a control group(homocysteine<10 mmol/L) according to the homocysteine levels on admission.The 24 hours heart rate variability of the both groups were observed,and the correlation between heart rate variability and target organ damage were analyzed.Results When compared with the control group,patients in the observation group got a decreased in SDNN(89.75±18.28 vs. 104.38±22.71 ms,P=0.000)；a lower level of SDANN(92.47±13.47 vs. 101.72±15.28 ms,P=0.000)；a lower level of SDNN-Index(33.29±8.73 vs. 40.67±10.38 ms,P=0.000)；a reduce in rMSSD(27.48±9.12 vs. 31.84±10.55 ms,P=0.010)；a lower level of PNN50(9.21±5.38 vs. 15.38±8.91%,P=0.000)；an elevated level of carotid intima-media thickness(0.97±0.12 vs.0.89±0.14 mm,P=0.000)；and an increased in left ventricular mass index(132.48±21.48 vs. 122.48±22.72 g/m2,P=0.008).SDNN,SDNN-Index and PNN50 were significantly negatively correlated with carotid intima media thickness,while SDNN,SDANN,SDNN-Index,rMSSD and PNN50 were significantly negatively correlated with left ventricular mass index(P<0.05). Conclusion The heart rate variability in patients with Htype hypertension is significantly reduced,which is related to the damage of target organs. |
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