| 闫学朋,毛古燧,付俊,等.血清骨代谢标志物在类风湿关节炎诊疗中的意义[J].安徽医药,2019,23(3):434-436. |
| 血清骨代谢标志物在类风湿关节炎诊疗中的意义 |
| The important role of bone metabolic markers in the diagnosis and treatment of rheumatoid arthritis and to understand the research progress of bone metabolic markers |
| 投稿时间：2016-10-09 |
| DOI： |
| 中文关键词: 骨代谢标志物 类风湿关节炎 研究进展 |
| 英文关键词: Bone turnover markers Rheumatoid arthritis Research progress |
| 基金项目:国家自然科学基金(81473672)；国家临床重点专科中医风湿病科建设项目(财社[2013]239号)；安徽省自然科学基金(1208085MH180)血清骨代谢标志物在类风湿关节炎诊疗中的意义闫学朋,毛古燧,付俊,黄传兵 (安徽中医药大学第一附属医院风湿病科,安徽 合肥 230038) |
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| 中文摘要: |
| 查阅国内外近5年与骨代谢标志物和类风湿关节炎(RA)相关性文献,从中梳理骨代谢标志物与RA的诊疗及预后的相关性。早期骨代谢标志物敏感性高于放射学检查及一般的生化检查,骨代谢标志物的检测可以发现早期X线尚不能检测出的骨质破坏,这对于RA病人早期诊断及减少致残率都有重要意义。此外,病程发展过程中骨代谢指标与炎症的发展呈正相关,与疾病活动密切相关,医生可以据此对RA病人的治疗方案及时进行调整,进而改善RA病人预后。 |
| 英文摘要: |
| Researching the literature in the five years to analyze the correlation between the bone metabolic markers in serum and the diagnosis and treatment of rheumatoid arthritis.Bone metabolic markers plays an important role in the diagnosis and prognosis of rheumatoid arthritis and it has higher sensitivity than ordinary biochemical indexes in the early stage of RA.Meanwhile,it was positively associated with the development of inflammation and closely associated with disease activity.To measure the levels of bone metabolism index can make a rational judgment of the prognosis of patients with RA.The early bone destruction which cannot be discovered by X-ray,can be find out through detecting bone metabolic markers.It is of great significance for early diagnosis of RA.It can reduce disability rate of RA.Bone metabolic markers can also reflect the progression of disease.Doctors can adjust the treatment plan timely based on it,by which RA patients can achieve good prognosis.To conclude,the bone metabolic markers in serum are with properties of high specificity and sensitivity in the diagnosis,treatment and disease development of RA. |
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