| 杨焕丹,张锐锋,彭倩倩,等.过敏性紫癜合并链球菌感染的临床特点及血清免疫球蛋白和补体的变化[J].安徽医药,2019,23(3):483-486. |
| 过敏性紫癜合并链球菌感染的临床特点及血清免疫球蛋白和补体的变化 |
| The changes of immunoglobulin and complement levels of children with Henoch-Schonlein purpura concurrent with streptococcal infection |
| 投稿时间：2017-03-08 |
| DOI： |
| 中文关键词: HSP合并链球菌感染在较大年龄男童更常见,实验室检查以严重的体液免疫功能紊乱及低补体血症为主,临床能增加关节肿痛的发生率,对腹痛及肾脏损害的发生率无明显影响。但其远期的损害有待进一步研究。 关键词:过敏性紫癜 链球菌感染 免疫球蛋白 补体 |
| 英文关键词: Henoeh-schonlein purpura Hemolytic streptococcus Immunoglobulin Complement |
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| 中文摘要: |
| 目的 探讨过敏性紫癜(HSP)合并链球菌感染的临床特点,为HSP防治提供依据。 方法 研究对象为435例HSP患儿,根据血抗链球菌溶血素O(ASO)检查分为两组,HSP合并链球菌感染者为HSP+ASO组78例,HSP不合并链球菌感染者为HSP-ASO组357例,同时选用30例健康儿童作为对照组。分析各组患儿临床特点、血清免疫球蛋白IgA、IgM、IgG及补体C3、C4的变化。 结果(1)HSP发病以秋冬季节为主,男童多于女童。链球菌感染阳性率为17.93%,HSP+ASO组关节肿痛发生率及年龄较HSP-ASO组偏高。与HSP-ASO组相比,HSP+ASO组男童所占的比例偏高,差异有统计学意义(χ2=5.035,P=0.025)。而两组间腹痛及肾脏损害差异无统计学意义(χ2=0.256,P=0.613)；(2)与HSP-ASO组相比,HSP+ASO组血清IgG、IgA有明显增高(t=4.68,t=3.20,P=0.000,P=0.002)；(3)与HSP-ASO组相比,HSP+ASO组血清C3、C4有下降(t=2.49,t=2.43,P=0.025,P=0.023),而HSP-ASO组及对照组相比,血清C3、C4差异无统计学意义(t=1.26,t=1.31,P=0.206,P=0.200)；(4)各组血清IgM差异无统计学意义。 |
| 英文摘要: |
| Objective To observe the changes of immunoglobulin and complement levels of children with Henoch-Schonlein purpura (HSP) concurrent with streptococcal infection and explore the correlation between infection and HSP in humoral immunity. Methods 435 children with HSP were chosen and divided into two groups based on the ASO:78 cases in ASO positive group and 357 cases in ASO negative group,with 30 healthy children as the control.The plasma immunoglobulin IgA,IgM,IgG and complement C3,C4 were detected by automatic biochemistry analyzer. Results (1) Rates of streptococcal infection in children with HSP was 17.93%.Compared with the HSP-ASO group,rates of arthralgia and the age were higher in the HSP+ASO group,however the rates of abdominal pain,Henoch-Schnlein purpura nephritis (HSPN) were similar in the two HSP groups;(2) Compared with the control and HSP-ASO group,the levels of IgA,IgG were significantly increased in the HSP+ASO group (P<0.05).The IgA,IgG of HSP+ASO group and HSP-ASO group were with significant difference;(3) Compared with the control group and HSP-ASO group,the levels of C3,C4 were significantly decreased in the HSP+ASO group (P<0.05),while no difference was found between the control group and HSP-ASO groups;(4) The levels of IgM had no significantdifference in each group. Conclusion HSP children with streptococcal infection had significant disorder in immunoglobulin and complement.The incidence of significant sequelae such as HSPN between patients with and without streptococcal infection is no differ. |
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