文章摘要
李颢,姜海华,王新伟.外周血Th17细胞对大剂量地塞米松治疗免疫性血小板减少症长期疗效的预测价值[J].安徽医药,2019,23(3):517-519.
外周血Th17细胞对大剂量地塞米松治疗免疫性血小板减少症长期疗效的预测价值
Predictive value of Th17 cells on the long-term efficacy of high-dose dexamethasone in the treatment of patients with immune thrombocytopenia
投稿时间:2017-04-26  
DOI:
中文关键词: 初诊外周血Th17细胞比例有助于预测大剂量DXM在ITP的长期疗效。 关键词:免疫性血小板减少症  Th17细胞  地塞米松  疗效
英文关键词: Immune thrombocytopenia  Th17 cells  Dexamethasone  Efficacy
基金项目:
作者单位
李颢 汝南县人民医院检验科,河南 汝南 463300 
姜海华 汝南县人民医院检验科,河南 汝南 463300 
王新伟 汝南县人民医院血液科,河南 汝南 463300 
摘要点击次数: 2018
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中文摘要:
      目的 评价免疫性血小板减少症(ITP)病人外周血Th17细胞比例对大剂量地塞米松(DXM)长期疗效的预测价值。 方法 采用流式细胞术检测42例初诊ITP病人外周血Th17细胞比例,分析Th17细胞比例在持续反应组病人(15例)及复发组(18例)病人之间的差异,应用受试者工作曲线法(ROC)分析Th17细胞比例对大剂量DXM长期疗效的预测价值。 结果 复发组病人治疗前外周血Th17细胞比例显著高于持续反应组病人(P<0.01)。应用治疗前外周血Th17细胞比例预测大剂量DXM的长期疗效,其曲线下面积为0.857(95% CI:0.717~0.998,P<0.01),cut-off值为1.235%。
英文摘要:
      Objective To assess the value of Th17 cells on predicting long-term efficacy of high-dose dexamethasone (DXM) in the treatment of patients with immune thrombocytopenia (ITP). Methods Flow cytometry was used to detect Th17 cells in 42 newly-diagnosed ITP patients,and the difference of Th17 ratios was compared between sustained responders and relapsed patients.The predictive efficiency of Th17 cells on long-term efficacy of high-dose DXM was evaluated by receiver operating characteristics (ROC) curve analysis. Results The ratio of Th17 cells at diagnosis in relapsed ITP patients was significantly higher than that in sustained responders (P<0.01).When long-term efficacy of high-dose DXM was evaluated by ROC curve analysis,the area under curve was 0.857(95% CI:0.717-0.998,P<0.01),cut-off value of Th17 cells ratio was 1.235%. Conclusion Ratios of Th17 cells in peripheral blood at diagnosis were useful for predicting the long-term efficacy of high-dose DXM in ITP patients.
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