| 张文富,黄晶晶,黄鸿娜,等.鳖甲煎丸辅助治疗乙肝后肝纤维化的疗效观察[J].安徽医药,2019,23(3):584-587. |
| 鳖甲煎丸辅助治疗乙肝后肝纤维化的疗效观察 |
| Effect of Biejiajian pill on the liver fibrosis after hepatitis B |
| 投稿时间：2018-01-18 |
| DOI： |
| 中文关键词: 在常规治疗的基础上,辅助鳖甲煎丸治疗乙肝后肝纤维化具有一定的疗效,有助于抵抗肝纤维化和改善肝功能。 关键词:鳖甲煎丸 乙型肝炎 肝纤维化 临床疗效 |
| 英文关键词: Biejiajian pills Hepatitis B Liver Fibrosis Clinical Efficacy |
| 基金项目:国家自然科学基金项目(81403382、81760845)鳖甲煎丸辅助治疗乙肝后肝纤维化的疗效观察张文富1,黄晶晶1,黄鸿娜1,王振常1,林才志2,於丽丽1,潘哲1 (1.广西中医药大学第一附属医院中西医结合内科,广西 南宁 530023;2.广西中医药大学第一附属医院中医内科,广西 南宁 53002) |
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| 中文摘要: |
| 目的 探讨鳖甲煎丸辅助治疗乙肝后肝纤维化的临床疗效。 方法 选取2015年1—12月广西中医药大学第一附属医院收治的乙肝后肝纤维化病人150例,将其采用随机数字表法分为观察组和对照组,每组75例,对照组给予常规护肝、抗病毒药物治疗,观察组在对照组治疗的基础上给予鳖甲煎丸治疗,两组病人均连续治疗6个疗程后,比较两组病人治疗前后血清肝纤维化指标,透明质酸(HA)、Ⅳ型胶原(Ⅳ-C)、层黏蛋白(LN)的变化情况；肝功能相关指标,谷氨酸氨基转移酶(AST)、天冬氨酸氨基转移酶(ALT)、总胆红素(TBIL)白蛋白(ALB)及白蛋白/球蛋白(A/G)的变化情况；肝纤维化和炎症的改善情况；不良反应的发生情况。 结果与治疗前比较,治疗后观察组HA[(313.78±50.69) vs. (90.39±25.41) μg/L]、IV-C[(139.16±30.97) vs. (63.38±19.34) μg/L]、LN[(180.16±34.05) vs. (102.29±1.24) μg/L],明显降低,对照组病人血清HA、Ⅳ-C、LN值也明显降低(P<0.05),且观察组显著低于对照组(P<0.05)；两组病人血清ALT、AST值显著低于治疗前(P<0.05),且观察组病人血清AST、ALT值显著低于对照组(P<0.05)；两组病人肝纤维化和炎症评分显著低于治疗前(P<0.05),且观察组病人肝纤维化和炎症评分显著低于对照组(P<0.05)；两组病人在服药期间均未出现严重不良反应。 |
| 英文摘要: |
| Objective To evaluate the clinical efficacy of Biejiajian pill in the treatment of posthepatitic liver fibrosis. Methods A total of 150 patients with posthepatitic cirrhosis after hepatitis Bin our hospital from January 2015 to December 2015 were selected and randomly divided into observation group and control group,with 75 cases in each group.The control group was given conventional hepatoprotective and antiviral therapy.The observation group was treated with BJJ on the basis of the control group.After two courses of continuous treatment for 6 courses,the serum levels of liver fibrosis,hyaluronic acid (HA),type Ⅳ collagen (Ⅳ-C) and laminin (LN) were observed.The indexes of liver function,aspartate aminotransferase (AST),alanine aminotransferase (ALT),total bilirubin (ALB) and albumin / Globulin (A / G) changes;improvement of liver fibrosis and inflammation;adverse reactions occurred. Results Compared with those before treatment,the levels of HA[(313.78±50.69) vs. (90.39±25.41) μg/L],IV-C[(139.16±30.97) vs. (63.38±19.34) μg/L] and LN[(180.16±34.05) vs. (102.29±1.24) μg/L] in the observation group and the control group were significantly decreased (P<0.05),and the observation group was significantly lower than the control group (P<0.05).Serum ALT and AST values were significantly lower in the two groups than in the control group (P<0.05).The levels of serum AST and ALT in the observation group were significantly lower than those in the control group (P<0.05).The scores of liver fibrosis and inflammation in the observation group were significantly lower than those in the control group (P<0.05).Two groups of patients during the medication did not appear serious adverse reactions. Conclusion On the basis of conventional therapy,the treatment of liver fibrosis with hepatitis Bafter treatment of hepatitis Bhas certain curative effect,which is helpful to resist liver fibrosis and improve liver function. |
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