| 赵玉,吕德珍,滕成玲.依达拉奉联合帕瑞昔布钠对腔镜辅助下胃癌根治术麻醉苏醒期躁动的影响[J].安徽医药,2019,23(3):591-593. |
| 依达拉奉联合帕瑞昔布钠对腔镜辅助下胃癌根治术麻醉苏醒期躁动的影响 |
| The effect of parecoxib sodium combined with edaravone on the incidence of restlessness during anesthesia emergence in gastric cancer patients with laparoscopic operation |
| 投稿时间：2017-03-20 |
| DOI： |
| 中文关键词: 帕瑞昔布钠联合依达拉奉可有效抑制术后苏醒期躁动的发生,可能机制与镇痛、炎症及氧化应激反应的抑制有关。 关键词:躁动 胃癌 依达拉奉 帕瑞昔布钠 |
| 英文关键词: Restlessness Gastric cancer Parecoxib sodium Edaravone |
| 基金项目: |
|
| 摘要点击次数: 2224 |
| 全文下载次数: 547 |
| 中文摘要: |
| 目的 探讨帕瑞昔布钠单用或联合依达拉奉对于行腔镜手术的胃癌病人麻醉苏醒期躁动发生率的影响,并探讨可能的作用机制。 方法 选取自2014年1月至2017年1月在中国人民解放军东部战区京总医院麻醉科行择期腔镜辅助下胃癌根治术的病人的资料。入组病人根据给药方案采用随机数字表法分为:A组(依达拉奉+帕瑞昔布钠组),B组(帕瑞昔布钠组)和C组(生理盐水对照组)。比较三组病人的基线资料,拔管时镇静、躁动情况、疼痛、镇静评分、平均动脉压(MAP)、心率(HR)水平,拔管时炎症及氧化损伤指标等。 结果 共纳入125例病人,其中A组45例,B组39例,C组41例。A、B、C三组病人的镇静(轻度34比21比18例,深度10比5比2例)、躁动情况(中度4比5比13例,重度1比5比10例)、MAP[(91.3±8.8)比(101.2±9.7)比(117.5±12.2) mmHg]、HR[(81.4±7.8)比(89.1±8.9)比(100.4±10.3)次/分]及氧化损伤指标组间差异有统计学意义,且A组病人镇静最佳、躁动最轻,MAP、HR、丙二醛(MDA)最低,还原型谷胱甘肽(GSH)、超氧化物歧化酶(SOD)最高,而C组病人正好相反(P<0.05)。 |
| 英文摘要: |
| Objective To discuss the effect of Parecoxib sodium combined with edaravone on the incidence of restlessness during anesthesia emergence in gastric cancer patients with laparoscopic operation and investigate possible involved mechanisms. Methods Clinical data of patients who underwent laparoscopic radical gastrectomy for gastric cancer in our hospital from 2014 to 2017 was collected.Patients were divided into three groups according to the treatment,group A (Parecoxib sodium combined with edaravone),group B (Parecoxib sodium) and group C (normal saline as control).The baseline information,calm and restlessness status,pain and sedation scores,MAP[(91.3±8.8) vs.(101.2±9.7) vs.(117.5±12.2) mmHg],HR levels[(81.4±7.8) vs.(89.21±8.9) vs.(100.4±10.3)],inflammation and oxidative damage indexes while drawing tube among three groups were compared. Results A total of 125 patients were retrospectively analyzed,including 45 in group A,39 in group Band 41 in group C.The calm and restlessness status,MAP,HR levels,inflammation and oxidative damage indexes while drawing tube were with significant difference among three groups.The levels of MAP,HR,MDA and the restlessness status in group Awere the lowest,while the levels of GSH and SOD were the highest,which were exactly the opposite in group C. Conclusion The treatment of Parecoxib sodium combined with Edaravone could significantly reduce the incidence of restlessness in gastric cancer patients with laparoscopic operation.The involved mechanisms were probably associated with analgesia,the suppression of inflammatory and oxidative stress response. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
